Evento

Deciphering cross-resistance mechanisms associated to targeted therapies and immunotherapy in BRAFmutmelanoma: The role of tumor-associated macrophages and galectin-1

Veigas, FlorenciaIcon ; Mahmoud, Yamil DamiánIcon ; Merlo, Joaquín PedroIcon ; Manselle Cocco, Montana NicolleIcon ; Massaro, MoraIcon ; Gatto, Sabrina GiselaIcon ; Morales, Rosa MaríaIcon ; Girotti, Maria RominaIcon ; Pérez Sáez, Juan ManuelIcon ; Rabinovich, Gabriel AdriánIcon
Tipo del evento: Reunión
Nombre del evento: AACR Annual Meeting 2023: Advancing the frontiers of cancer science and medicine
Fecha del evento: 14/04/2023
Institución Organizadora: American Association for Cancer Research;
Título de la revista: Cancer Research
Editorial: American Association for Cancer Research
ISSN: 0008-5472
e-ISSN: 1538-7445
Idioma: Inglés
Clasificación temática:

Resumen

Both targeted therapies (TT) and immunotherapies have revolutionized the treatment of metastatic melanoma patients. Particularly, TT with BRAFi or BRAFi/MEKi leads to prompt but not durable responses in most patients due to the development of resistance within 1 year. Tumors refractory to TT derive little benefit from subsequent immunotherapy. Here we aim to elucidate how previous treatments with TT shape tumor-immune landscape and how it could be overcome therapeutically.
Palabras clave: MELANOMA , GALECTIN-1
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/264973
URL: https://aacrjournals.org/cancerres/article/83/7_Supplement/2261/719797/Abstract-
DOI: http://dx.doi.org/10.1158/1538-7445.AM2023-2261
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Eventos(IBYME)
Eventos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Deciphering cross-resistance mechanisms associated to targeted therapies and immunotherapy in BRAFmutmelanoma: The role of tumor-associated macrophages and galectin-1; AACR Annual Meeting 2023: Advancing the frontiers of cancer science and medicine; Orlando; Estados Unidos; 2023; 2261-2261
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