Differential expression of CPB1 and CRISP3 in luminal breast cancer models treated with mifepristone and medroxyprogesterone acetate

Abstract

Several epidemiological studies, supported by experimental research,suggest that progestins exert a relevant role in breast carcinogenesis.Thus, there is an increased interest in targeting progesteronereceptors (PR) for breast cancer treatment. We have recentlyshown that the antiprogestin mifepristone (MFP) inhibited cell proliferationof breast cancer tissue cultures with higher levels of PR isoformA (PRA) than B (PRB), highlighting the relevance of identifyingmarkers to monitor antiprogestin responsiveness. Using RNA-seqwe have previously identified 139 genes differentially expressedin breast carcinomas with high or low PRA/PRB ratio (PRA-H andPRB-H, respectively).