Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets

Abstract

Aim: This study focused on ev alua ting the influence of geometric dimensions on the drug release kinetics of 3D-printed tablets. M aterials & metho ds: An ink based on Gelucire 50/13 was pr epar ed to print ivermectin-loaded tablets. The ink was characterized phy sic ochemically and tablet dissolution tests w er e car r ied out. Results: The results confirmed the suitability of the ink for 3D printing at a temperature > 46 ◦C. Changes in the crystallinity of iv ermectin w er e observ ed without chemical interactions with the polymer. 3D printed tablets with varied proportional sizes showed dual behavior in their release profiles, while tablets with only thickness reduction exhibited zero-order kinetics. Conclusion: These findings highlight the versatility of 3D printing t o creat e sy st ems with specific and customized release profiles.