Evento

Blockade of retrograde transport in triple negative breast cancer excludes ErbB-2 isoforms from the nucleus and abrogates tumor growth

Madera, SantiagoIcon ; Izzo, FrancoIcon ; Chervo, María FlorenciaIcon ; Dupont, Agustina; Chiauzzi, Violeta AliciaIcon ; Bruni, SofiaIcon ; Petrillo, EzequielIcon ; Montero, Diego; Merin, Sharon S.; Mercogliano, María FlorenciaIcon ; Proietti, Cecilia; Schillaci, RoxanaIcon ; Cordo Russo, Rosalia InesIcon ; Elizalde, Patricia VirginiaIcon
Tipo del evento: Reunión
Nombre del evento: American Association for Cancer Research Annual Meeting 2022
Fecha del evento: 08/04/2022
Institución Organizadora: American Association for Cancer Research;
Título de la revista: Cancer Research
Editorial: American Association for Cancer Research
ISSN: 0008-5472
e-ISSN: 1538-7445
Idioma: Inglés
Clasificación temática:

Resumen

Triple negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of the receptor tyrosine kinase ErbB-2/HER2. Due to its heterogeneity, clinical biomarkers and targeted therapies for this disease remain elusive, and chemotherapy has been the standard of care for early and metastatic TNBC. ErbB-2 is classically located at the membrane of BC cells, where it triggers signalling cascades and promotes oncogenesis.
Palabras clave: NUCLEAR ERBB2 , BREAST CANCER
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/264371
DOI: https://doi.org/10.1158/1538-7445.AM2022-344
URL: https://aacrjournals.org/cancerres/article/82/12_Supplement/344/701776/Abstract-
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Eventos(IBYME)
Eventos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Blockade of retrograde transport in triple negative breast cancer excludes ErbB-2 isoforms from the nucleus and abrogates tumor growth; American Association for Cancer Research Annual Meeting 2022; New Orleans; Estados Unidos; 2022; 344-344
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