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dc.contributor.author Mondillo, Carolina
dc.contributor.author Falus, Andras
dc.contributor.author Pignataro, Omar Pedro
dc.contributor.author Pap, Erna
dc.date.available 2017-10-09T20:56:09Z
dc.date.issued 2007-01
dc.identifier.citation Mondillo, Carolina; Falus, Andras; Pignataro, Omar Pedro; Pap, Erna; Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function; American Society of Andrology; Journal of Andrology; 28; 1; 1-2007; 86-91
dc.identifier.issn 0196-3635
dc.identifier.uri http://hdl.handle.net/11336/26291
dc.description.abstract The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we performed experiments using highly purified Leydig cells in culture, isolated from wild type (WT) and histidine decarboxylase (Hdc) gene knockout (HDC KO)-so HA-deprived-mice. HDC KO Leydig cells showed lower basal and human choriogonadotropin (hCG)-induced testosterone production compared to WT Leydig cells, presumably due to altered P450scc gene (Cyp11a1) expression levels. Moreover, in HDC KO cells, hCG did not increase basal expression levels of HA H1 and H2 receptor genes, while the hormone showed a significant inducing effect in WT cells. Based on these findings, we propose that prolonged HA deficiency in HDC KO mice affects various aspects of Leydig cell physiology, most importantly the response to hCG, providing definite evidence that HA plays a role as direct modulator of Leydig cell function and steroid synthesis in the testis. Also, the results presented herein constitute the first molecular evidence for the expression of HA H1 and H2 receptor subtypes in isolated Leydig cells.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Society of Andrology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject HUMAN CHORIOGONADOTROPIN
dc.subject STEROIDOGENESIS
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-10-06T18:01:53Z
dc.identifier.eissn 1939-4640
dc.journal.volume 28
dc.journal.number 1
dc.journal.pagination 86-91
dc.journal.pais Estados Unidos
dc.journal.ciudad Illinois
dc.description.fil Fil: Mondillo, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Falus, Andras. Semmelweis Egyetem; Hungría
dc.description.fil Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil Fil: Pap, Erna. Semmelweis Egyetem; Hungría
dc.journal.title Journal of Andrology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.2164/jandrol.106.000257/abstract
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2164/jandrol.106.000257


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)