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dc.contributor.author
Mondillo, Carolina
dc.contributor.author
Falus, Andras
dc.contributor.author
Pignataro, Omar Pedro
dc.contributor.author
Pap, Erna
dc.date.available
2017-10-09T20:56:09Z
dc.date.issued
2007-01
dc.identifier.citation
Mondillo, Carolina; Falus, Andras; Pignataro, Omar Pedro; Pap, Erna; Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function; American Society of Andrology; Journal of Andrology; 28; 1; 1-2007; 86-91
dc.identifier.issn
0196-3635
dc.identifier.uri
http://hdl.handle.net/11336/26291
dc.description.abstract
The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we performed experiments using highly purified Leydig cells in culture, isolated from wild type (WT) and histidine decarboxylase (Hdc) gene knockout (HDC KO)-so HA-deprived-mice. HDC KO Leydig cells showed lower basal and human choriogonadotropin (hCG)-induced testosterone production compared to WT Leydig cells, presumably due to altered P450scc gene (Cyp11a1) expression levels. Moreover, in HDC KO cells, hCG did not increase basal expression levels of HA H1 and H2 receptor genes, while the hormone showed a significant inducing effect in WT cells. Based on these findings, we propose that prolonged HA deficiency in HDC KO mice affects various aspects of Leydig cell physiology, most importantly the response to hCG, providing definite evidence that HA plays a role as direct modulator of Leydig cell function and steroid synthesis in the testis. Also, the results presented herein constitute the first molecular evidence for the expression of HA H1 and H2 receptor subtypes in isolated Leydig cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Andrology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Human Choriogonadotropin
dc.subject
Steroidogenesis
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-06T18:01:53Z
dc.identifier.eissn
1939-4640
dc.journal.volume
28
dc.journal.number
1
dc.journal.pagination
86-91
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Illinois
dc.description.fil
Fil: Mondillo, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Falus, Andras. Semmelweis Egyetem; Hungría
dc.description.fil
Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Pap, Erna. Semmelweis Egyetem; Hungría
dc.journal.title
Journal of Andrology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.2164/jandrol.106.000257/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2164/jandrol.106.000257


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  • Articulos(IBYME) [1101]
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