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Artículo

Age-of-onset of menopause is associated with enhanced painful and non-painful sensitivity in fibromyalgia

Martinez Jauand, Mercedes; Sitges Quirós, Carol; Femenia, Joan Reines; Cifre, Ignacio; Gonzalez, Susana LauraIcon ; Chialvo, Dante RenatoIcon ; Montoya Jimenez, Pedro José
Fecha de publicación: 16/02/2013
Editorial: Springer
Revista: Clinical Rheumatology.
ISSN: 0770-3198
e-ISSN: 1434-9949
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Fibromyalgia (FM) is a chronic pain condition characterized by high prevalence in women. In particular, estrogen deficit has been considered as a potentially promoting factor of FM symptoms. This study was aimed to examine the relationship between age-of-onset of menopause and pain sensitivity in FM. For this purpose, pain sensitivity was assessed in 74 FM and 32 pain-free control women. All participants were postmenopausal and underwent a detailed semi-structured clinical interview, including data about menopause transition, previous history of hysterectomy or ovariectomy, and menses time. Participants were divided into two groups depending on age-of-onset of menopause: early menopause [≤49 years] vs. late menopause [>49 years]. Pain and non-pain thresholds were assessed by using cold, heat, mechanical, and electrical stimulation. FM women showed higher overall pain sensitivity as compared with healthy subjects. FM women with early age-of-onset of menopause displayed greater pain and non-pain sensitivity than FM women with late age-of-onset of menopause, whereas no differences were observed in healthy women due to age-of-onset of menopause. These results suggest that an early transition to menopause (shortening the time of exposure to estrogens) may influence pain hypersensitivity and could be related to aggravation of FM symptoms.
Palabras clave: Fibromyalgia , Menopause , Non-Pain Thresholds , Estrogen , Pain Thresholds
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/2621
DOI: http://dx.doi.org/ 10.1007/s10067-013-2212-8
URL: http://link.springer.com/article/10.1007%2Fs10067-013-2212-8
URL: http://www.ncbi.nlm.nih.gov/pubmed/23417348
DOI: http://dx.doi.org/10.1007/s10067-013-2212-8
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Martinez Jauand, Mercedes; Sitges Quirós, Carol; Femenia, Joan Reines; Cifre, Ignacio; Gonzalez, Susana Laura; et al.; Age-of-onset of menopause is associated with enhanced painful and non-painful sensitivity in fibromyalgia; Springer; Clinical Rheumatology.; 32; 7; 16-2-2013; 975-981
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