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dc.contributor.author
Costanza, Vicente
dc.contributor.author
Rivadeneira Paz, Pablo Santiago
dc.contributor.author
Biafore, Federico Leonardo
dc.contributor.author
D'attellis, Carlos Enrique
dc.date.available
2017-10-06T19:27:19Z
dc.date.issued
2009-12
dc.identifier.citation
Costanza, Vicente; Rivadeneira Paz, Pablo Santiago; Biafore, Federico Leonardo; D'attellis, Carlos Enrique; A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection; Elsevier; Biomedical Signal Processing and Control; 4; 2; 12-2009; 139-148
dc.identifier.issn
1746-8094
dc.identifier.uri
http://hdl.handle.net/11336/26151
dc.description.abstract
Antiretroviral therapies allowing for regular medical intervention in an optimal feedback role are substantiated. Individual therapies are evaluated from a multi-objective cost perspective, under different time and history constrains. The dynamics of the control system is governed by three state variables: healthy T-cells, infected T-cells, and viral particles. The drug dose administrated to the patient is taken as the manipulated or control variable. Illustrations of the methodology employed are provided for a fixed time-horizon of 180 days and variable prescription intervals, inverse discount factors, state discretization, and thresholds. Two cases are discussed: (i) beginning of the infection and (ii) near endemic equilibrium. Both open-loop and closed-loop results are presented. Dynamic Programming has been employed in the numerical treatment of the problem. Safety recommendations are also designed to cope with the chaotic behavior of the free dynamics’ flow in critical regions of the states’ domain. A software package is envisioned to assist physicians in assessing the patient ‘‘state’’, estimating antiretroviral dose prescriptions for the whole treatment period, simulating the patient’s evolution, eventually correcting the original sequence in presence of incoming data, and evaluating combined costs of alternative treatment strategies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hiv
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Antiretroviral Drugs
dc.subject
Optimal Control
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Nonlinear Dynamics
dc.subject.classification
Otras Ingeniería Química
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Ingeniería Química
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
A Closed-Loop Approach to Antiretroviral Therapies for HIV Infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-04T14:51:18Z
dc.journal.volume
4
dc.journal.number
2
dc.journal.pagination
139-148
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina
dc.description.fil
Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: D'attellis, Carlos Enrique. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnología. Centro de Matemática Aplicada; Argentina. Universidad Favaloro; Argentina
dc.journal.title
Biomedical Signal Processing and Control
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bspc.2009.02.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809409000147


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