Artículo
Influence of cross-linking density on swelling and estradiol permeation of chitosan membranes
Fecha de publicación:
02/2010
Editorial:
Springer
Revista:
Journal of Materials Science
ISSN:
0022-2461
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
Chitosan membranes were obtained by a casting/solvent evaporation method and cross-linking with sodium tripolyphosphate. The effect of cross-linking time was studied and the cross-linked membranes were characterized with respect to equilibrium water content, sodium content, IR spectroscopy and permeability to a model drug (Estradiol). Sodium content increased with increasing cross-linking time. Equilibrium water content was higher in the membrane with the lowest cross-linking time. This membrane also showed a higher flux of Estradiol compared with the other which exhibited an increment in equilibrium water content and flux of Estradiol with the increase in cross-linking duration. These dissimilar results could be explained by a significant correlation between the hydrophilicity of the membrane and the hydrophobicity of Estradiol.
Palabras clave:
Chitosan Membranes
,
Cross-Linking
,
Estradiol
,
Water Content
,
Drug Permeation
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Mengatto, Luciano Nicolas; Luna, Julio Alberto; Cabrera, Maria Ines; Influence of cross-linking density on swelling and estradiol permeation of chitosan membranes; Springer; Journal of Materials Science; 45; 4; 2-2010; 1046-1051
Compartir
Altmétricas