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dc.contributor.author
Bernardi, Larissa S.
dc.contributor.author
Ferreira, Fábio F.
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Cuffini, Silvia Lucia
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dc.contributor.author
Campos, Carlos E. M.
dc.contributor.author
Monti, Gustavo Alberto
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dc.contributor.author
Kuminek, Gislaine
dc.contributor.author
Oliveira, Paulo R.
dc.contributor.author
Cardoso, Simone G.
dc.date.available
2017-10-05T20:02:38Z
dc.date.issued
2013-09
dc.identifier.citation
Bernardi, Larissa S.; Ferreira, Fábio F.; Cuffini, Silvia Lucia; Campos, Carlos E. M. ; Monti, Gustavo Alberto; et al.; Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method; Elsevier Science; Talanta; 117; 9-2013; 189-195
dc.identifier.issn
0039-9140
dc.identifier.uri
http://hdl.handle.net/11336/26037
dc.description.abstract
Venlafaxine hydrochloride (VEN) is an antidepressant drug widely used for the treatment of depression. The purpose of this study was to carry out the preparation and solid state characterization of the pure polymorphs (Forms 1 and 2) and the polymorphic identification and quantification of four commercially-available VEN raw materials. These two polymorphic forms were obtained from different crystallization methods and characterized by X-ray Powder Diffraction (XRPD), Diffuse Reflectance Infrared Fourier Transform (DRIFT), Raman Spectroscopy (RS), liquid and solid state Nuclear Magnetic Resonance (NMR and ssNMR) spectroscopies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) techniques. The main differences were observed by DSC and XRPD and the latter was chosen as the standard technique for the identification and quantification studies in combination with the Rietveld method for the commercial raw materials (VEN1–VEN4) acquired from different manufacturers. Additionally Form 1 and Form 2 can be clearly distinguished from their 13C ssNMR spectra. Through the analysis, it was possible to conclude that VEN1 and VEN2 were composed only of Form 1, while VEN3 and VEN4 were a mixture of Forms 1 and 2. Additionally, the Rietveld refinement was successfully applied to quantify the polymorphic ratio for VEN3 and VEN4.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Venlafaxine Hydrochloride
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Polymorphism
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X-Ray Powder Diffraction
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Rietveld Method
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Otras Ciencias Químicas
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Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-10-03T18:23:08Z
dc.journal.volume
117
dc.journal.pagination
189-195
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil
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Fil: Ferreira, Fábio F.. Universidade Federal do ABC; Brasil
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Fil: Cuffini, Silvia Lucia. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Campos, Carlos E. M.. Universidade Federal de Santa Catarina; Brasil
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Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
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Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil
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Fil: Oliveira, Paulo R.. Universidade Estadual do Centro Oeste; Brasil
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Fil: Cardoso, Simone G.. Universidade Federal de Santa Catarina; Brasil
dc.journal.title
Talanta
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.talanta.2013.09.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914013007340
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