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Artículo

Genotoxicity and oxidative stress in fish after a short-term exposure to silver nanoparticles

Bacchetta, CarlaIcon ; Ale, AnalíaIcon ; Simoniello, Maria Fernanda; Gervasio, Susana GracielaIcon ; Davico, Carla; Rossi, Andrea SilvanaIcon ; Desimone, Martín FedericoIcon ; Poletta, Gisela LauraIcon ; Lopez, Gerardo DanielIcon ; Monserrat, José María; Cazenave, JimenaIcon
Fecha de publicación: 05/2017
Editorial: Elsevier
Revista: Ecological Indicators
ISSN: 1470-160X
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

This study examined the effects of waterborne silver nanoparticles (AgNPs) on juvenile fish Piaractus mesopotamicus (“pacú”), and analyzed toxicological endpoints such as metal burdens, oxidative stress and genotoxicity in a short-term assay. Fish were individually exposed to 0 (control), 2.5, 10, and 25 μg AgNPs/L. After 24 h, silver accumulation was greater in the brain than the liver and gills at all silver concentrations. Fish exposed to higher AgNPs concentrations showed major alterations in oxidative stress markers. An increase in lipid peroxidation (LPO) levels was observed in the liver of fish exposed to 10 μg AgNPs/L with no changes in the antioxidant enzymes activities. In the case of the 25 μg AgNPs/L treatment, a hepatic activation of the enzymatic antioxidant defense occurred, and LPO levels resulted unaltered. On the other hand, the brain presented the highest LPO levels at both 10 and 25 μg AgNPs/L exposures. The AgNPs toxicity was also evidenced by the DNA damage in fish erythrocytes at higher concentrations. Summarizing, a short exposure to sublethal concentrations of AgNPs is enough to generate deleterious effects on fish, including DNA damage.
Palabras clave: Antioxidant Enzymes , Bioaccumulation , Biomarkers , Dna Damage , Lipid Peroxidation , Nanomaterials
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/25977
DOI: http://dx.doi.org/10.1016/j.ecolind.2017.01.018
URL: http://www.sciencedirect.com/science/article/pii/S1470160X17300249
Colecciones
Articulos(IQUIMEFA) [249]
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos(INTEC) [1556]
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos(INALI) [332]
Articulos de INST.NAC.DE LIMNOLOGIA (I)
Citación
Bacchetta, Carla; Ale, Analía; Simoniello, Maria Fernanda; Gervasio, Susana Graciela; Davico, Carla; et al.; Genotoxicity and oxidative stress in fish after a short-term exposure to silver nanoparticles; Elsevier; Ecological Indicators; 76; 5-2017; 230-239
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