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dc.contributor.author
Revsin, Yanina
dc.contributor.author
van Wijk, Diane
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dc.contributor.author
Saravia, Flavia Eugenia
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dc.contributor.author
Oitzl, Melly
dc.contributor.author
de Nicola, Alejandro Federico
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dc.contributor.author
de Kloet, Edo Ronald
dc.date.available
2017-10-04T19:33:39Z
dc.date.issued
2008
dc.identifier.citation
Revsin, Yanina; van Wijk, Diane; Saravia, Flavia Eugenia; Oitzl, Melly; de Nicola, Alejandro Federico; et al.; Adrenal hypersensitivity precedes chronic hypercoricism in streptozotocin-induced diabetes mice; Oxford University Press; Endocrinology; 149; 7; -1-2008; 3531-3539
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/25919
dc.description.abstract
Previous studies have demonstrated that type 1 diabetes is characterized by hypercorticism and lack of periodicity in adrenal hormone secretion. In the present study, we tested the hypothesis that hypercorticism is initiated by an enhanced release of ACTH leading subsequently to adrenocortical growth and increased output of adrenocortical hormones. To test this hypothesis, we used the streptozotocin (STZ)-induced diabetes mouse model and measured hypothalamic-pituitary-adrenal axis activity at different time points. The results showed that the expected rise in blood glucose levels induced by STZ treatment preceded the surge in corticosterone secretion, which took place 1 d after diabetes onset. Surprisingly, circulating ACTH levels were not increased and even below control levels until 1 d after diabetes onset and remained low until d 11 during hypercorticism. In response to ACTH (but not vasopressin), cultures of adrenal gland cells from 11-d diabetic mice secreted higher amounts of corticosterone than control cells. Real-time quantitative PCR revealed increased expression of melanocortin 2 and melanocortin 5 receptors in the adrenal glands at 2 and 11 d of STZ-induced diabetes. AVP mRNA expression in the paraventricular nucleus of the hypothalamus was increased, whereas hippocampal MR mRNA was decreased in 11-d diabetic animals. GR and CRH mRNAs remained unchanged in hippocampus and paraventricular nucleus of diabetic mice at all time points studied. These results suggest that sensitization of the adrenal glands to ACTH rather than an increase in circulating ACTH level is the primary event leading to hypercorticism in the STZ-induced diabetes mouse model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Diabetes
dc.subject
Glucocorticoid Receptor
dc.subject
Mineralocorticoid Receptor
dc.subject
Acth
dc.subject.classification
Reumatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Adrenal hypersensitivity precedes chronic hypercoricism in streptozotocin-induced diabetes mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-25T18:31:28Z
dc.identifier.eissn
1945-7170
dc.journal.volume
149
dc.journal.number
7
dc.journal.pagination
3531-3539
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Revsin, Yanina. Leiden University; Países Bajos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: van Wijk, Diane. Leiden University; Países Bajos
dc.description.fil
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Oitzl, Melly. Leiden University; Países Bajos
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: de Kloet, Edo Ronald. Leiden University; Países Bajos
dc.journal.title
Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2007-1340
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1210/en.2007-1340
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/18420743
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