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dc.contributor.author
Beauquis, Juan
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Homo Delarche, Francoise
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Revsin, Yanina
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de Nicola, Alejandro Federico
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Saravia, Flavia Eugenia
dc.date.available
2017-10-04T17:33:57Z
dc.date.issued
2008-07-29
dc.identifier.citation
Beauquis, Juan; Homo Delarche, Francoise; Revsin, Yanina; de Nicola, Alejandro Federico; Saravia, Flavia Eugenia; Brain alterations in autoimmune and pharmacological models of diabetes mellitus: focus on hypothalamic-pituitary-adrenocortical axis disturbances; Karger; Neuroimmunomodulation; 15; 1; 29-7-2008; 61-67
dc.identifier.issn
1021-7401
dc.identifier.uri
http://hdl.handle.net/11336/25875
dc.description.abstract
Type 1 diabetes (T1D) is linked to an 'encephalopathy' explained by some features common to the aging process, degenerative and functional disorders of the central nervous system. In the present study we describe a manifest hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in two different experimental mouse models of T1D including the pharmacological one induced by streptozotocin and the spontaneous NOD (nonobese diabetic mice). The high expression of hypothalamic hormones like oxytocin and vasopressin were part to this alteration, together with elevated adrenal glucocorticoids and prominent susceptibility to stress. In the hippocampus of diabetic animals a marked astrogliosis, often associated with neural damage, was present. Dentate gyrus neurogenesis was also affected by the disease: proliferation and differentiation measured by bromodeoxyuridine immunodetection were significantly reduced in both experimental models used. Several facts, including changes associated with chronic hyperglycemia, hyperstimulation of the HPA axis, increased levels of circulating glucocorticoids in combination with brain inflammation and low production of new neurons, contribute to emphasize the impact of diabetes on the central nervous system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASTROCYTES
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GLUCOCORTICOIDS
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HIPPOCAMPUS
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HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
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HYPOTHALAMUS
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NEUROGENESIS
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NONOBESE DIABETIC MICE
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STREPTOZOTOCIN
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TYPE 1 DIABETES
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VASOPRESSIN
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Brain alterations in autoimmune and pharmacological models of diabetes mellitus: focus on hypothalamic-pituitary-adrenocortical axis disturbances
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-25T18:30:01Z
dc.identifier.eissn
1423-0216
dc.journal.volume
15
dc.journal.number
1
dc.journal.pagination
61-67
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Beauquis, Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Homo Delarche, Francoise. Université Paris Diderot - Paris 7; Francia. Inserm; Francia
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Fil: Revsin, Yanina. Leiden University; Países Bajos
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.journal.title
Neuroimmunomodulation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/135625
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000135625
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/18667801
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