Mostrar el registro sencillo del ítem

dc.contributor.author
Rodig, Scott J.
dc.contributor.author
Ouyang, Jing
dc.contributor.author
Juszczynski, Przemyslaw
dc.contributor.author
Currie, Treeve
dc.contributor.author
Law, Kenneth
dc.contributor.author
Neuberg, Donna S.
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Shipp, Margaret A.
dc.contributor.author
Kutok, Jeffery L.
dc.date.available
2017-10-04T17:04:33Z
dc.date.issued
2008-06
dc.identifier.citation
Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; et al.; AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features; American Association for Cancer Research; Clinical Cancer Research; 14; 11; 6-2008; 3338-3344
dc.identifier.issn
1078-0432
dc.identifier.uri
http://hdl.handle.net/11336/25866
dc.description.abstract
Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association for Cancer Research
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lymphomas
dc.subject
Galectin-1
dc.subject
Ap-1
dc.subject
Signature
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-25T18:29:50Z
dc.identifier.eissn
1078-0432
dc.journal.volume
14
dc.journal.number
11
dc.journal.pagination
3338-3344
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Rodig, Scott J.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Ouyang, Jing. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Juszczynski, Przemyslaw. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Currie, Treeve. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Law, Kenneth. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Neuberg, Donna S.. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Shipp, Margaret A.. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Kutok, Jeffery L.. Harvard Medical School; Estados Unidos
dc.journal.title
Clinical Cancer Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18519761
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1158/1078-0432.CCR-07-4709


Archivos asociados

Documento no disponible

Comunidades y colecciones

  • Articulos(IBYME) [1100]
    Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Mostrar el registro sencillo del ítem