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dc.contributor.author Rodig, Scott J.
dc.contributor.author Ouyang, Jing
dc.contributor.author Juszczynski, Przemyslaw
dc.contributor.author Currie, Treeve
dc.contributor.author Law, Kenneth
dc.contributor.author Neuberg, Donna S.
dc.contributor.author Rabinovich, Gabriel Adrián
dc.contributor.author Shipp, Margaret A.
dc.contributor.author Kutok, Jeffery L.
dc.date.available 2017-10-04T17:04:33Z
dc.date.issued 2008-06
dc.identifier.citation Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; et al.; AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features; American Association for Cancer Research; Clinical Cancer Research; 14; 11; 6-2008; 3338-3344
dc.identifier.issn 1078-0432
dc.identifier.uri http://hdl.handle.net/11336/25866
dc.description.abstract Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Association for Cancer Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject LYMPHOMAS
dc.subject GALECTIN-1
dc.subject AP-1
dc.subject SIGNATURE
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-09-25T18:29:50Z
dc.identifier.eissn 1078-0432
dc.journal.volume 14
dc.journal.number 11
dc.journal.pagination 3338-3344
dc.journal.pais Estados Unidos
dc.journal.ciudad Philadelphia
dc.description.fil Fil: Rodig, Scott J.. Harvard Medical School; Estados Unidos
dc.description.fil Fil: Ouyang, Jing. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil Fil: Juszczynski, Przemyslaw. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil Fil: Currie, Treeve. Harvard Medical School; Estados Unidos
dc.description.fil Fil: Law, Kenneth. Harvard Medical School; Estados Unidos
dc.description.fil Fil: Neuberg, Donna S.. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Shipp, Margaret A.. Dana Farber Cancer Institute; Estados Unidos
dc.description.fil Fil: Kutok, Jeffery L.. Harvard Medical School; Estados Unidos
dc.journal.title Clinical Cancer Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18519761
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1158/1078-0432.CCR-07-4709


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)