Artículo
Galectins: structure, function and therapeutic potential
Fecha de publicación:
10/2008
Editorial:
Cambridge University Press
Revista:
Expert Reviews In Molecular Medicine
ISSN:
1462-3994
e-ISSN:
1462-3994
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectins are a family of animal lectins that bind beta-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes. However, galectins are also detectable in the cytosol and nucleus, and may influence cellular functions such as intracellular signalling pathways through protein-protein interactions with other cytoplasmic and nuclear proteins. Current research indicates that galectins play important roles in diverse physiological and pathological processes, including immune and inflammatory responses, tumour development and progression, neural degeneration, atherosclerosis, diabetes, and wound repair. Some of these have been discovered or confirmed by using genetically engineered mice deficient in a particular galectin. Thus, galectins may be a therapeutic target or employed as therapeutic agents for inflammatory diseases, cancers and several other diseases.
Palabras clave:
Galectins
,
Structure
,
Function
,
Therapy
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Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Ri Yao, Yang; Rabinovich, Gabriel Adrián; Fu Tong, Liu; Galectins: structure, function and therapeutic potential; Cambridge University Press; Expert Reviews In Molecular Medicine; 10; 10-2008; e17-e27
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