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dc.contributor.author
Argüello, José M.  
dc.contributor.author
Raimunda, Daniel Cesar  
dc.contributor.author
Padilla Benavidez, Teresita  
dc.date.available
2017-10-04T14:05:35Z  
dc.date.issued
2013-11  
dc.identifier.citation
Argüello, José M.; Raimunda, Daniel Cesar; Padilla Benavidez, Teresita; Mechanisms of copper homeostasis in bacteria; Frontiers; Frontiers in Cellular and Infection Microbiology; 3; 11-2013; 1-14; 73  
dc.identifier.issn
2235-2988  
dc.identifier.uri
http://hdl.handle.net/11336/25848  
dc.description.abstract
Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Copper  
dc.subject
Copper Homeostasis  
dc.subject
Transmembrane Transport  
dc.subject
Metalloenzymes  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Mechanisms of copper homeostasis in bacteria  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-10-03T18:23:22Z  
dc.journal.volume
3  
dc.journal.pagination
1-14; 73  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Argüello, José M.. Worcester Polytechnic Institute; Estados Unidos  
dc.description.fil
Fil: Raimunda, Daniel Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: Padilla Benavidez, Teresita. Worcester Polytechnic Institute; Estados Unidos  
dc.journal.title
Frontiers in Cellular and Infection Microbiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fcimb.2013.00073  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2013.00073/full