Astrocytic insulin signaling and inflammation in experimental Alzheimer's disease

Abstract

Insulin resistance (IR) and chronic inflammation are associated with the development of cognitive disorders and neurodegenerative diseases such as Alzheimer's (AD). However, it is not clear whether there is a causal link between these factors, which one appears earlier in the pathology or if either one of them is triggered by the increasing circulating levels of Aβ or amyloid deposits in early AD.