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dc.contributor.author
Marin, Maia Solange
dc.contributor.author
Quintana, Silvina
dc.contributor.author
Faverin, Claudia
dc.contributor.author
Leunda, M. R.
dc.contributor.author
Odeón, Anselmo Carlos
dc.contributor.author
Perez, Sandra
dc.date.available
2017-10-03T17:11:49Z
dc.date.issued
2014-02
dc.identifier.citation
Marin, Maia Solange; Quintana, Silvina; Faverin, Claudia; Leunda, M. R.; Odeón, Anselmo Carlos; et al.; Toll-like receptor activation and expression in bovine alpha-herpesvirus infections; Elsevier; Research in Veterinary Science; 96; 1; 2-2014; 196-203
dc.identifier.issn
0034-5288
dc.identifier.uri
http://hdl.handle.net/11336/25776
dc.description.abstract
The involvement of Toll-like receptors (TLRs) in bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) infections has not been analyzed. In this study, the role of TLR signaling on virus replication was investigated. Blood leukocytes consistently express TLRs. Thus, our approach was to study in vitro the effects of agonist stimulation of TLRs expressed by peripheral blood leukocytes on BoHV-1 and BoHV-5 replication. Furthermore, the patterns of TLRs 3, 7–9 expression on virus-infected-bovine leukocytes were analyzed. Only Imiquimod (TLR7/8 agonist) showed anti-viral activity on infected MDBK cells. This is the first evidence that the timely activation of TLR7/8 signaling is effective in impairing BoHV-1 and 5 replication, thereby providing an experimental indication that Imiquimod may be a promising immune modulator. This work describes, for the first time, the expression patterns of TLRs in BoHV-1- or BoHV-5-infected-bovine leukocytes, suggesting the involvement of TLR7 and TLR9 in the recognition of these viruses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Toll-Like Receptor
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Bovine Herpesvirus
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Agonist
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Expression Pattern
dc.title
Toll-like receptor activation and expression in bovine alpha-herpesvirus infections
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-29T14:45:27Z
dc.journal.volume
96
dc.journal.number
1
dc.journal.pagination
196-203
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Quintana, Silvina. Instituto de Análisis Fares Taie. Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Faverin, Claudia. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
dc.description.fil
Fil: Leunda, M. R.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
dc.description.fil
Fil: Odeón, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
dc.description.fil
Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Research in Veterinary Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528813003779
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.rvsc.2013.11.015
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