Regulation of the androgen receptor function by TPR-domain proteins

Abstract

Tetratricopeptide repeats (TPR) sequences of 34 amino acids arranged in tandems of antiparallel α-helices. They are responsible of protein-protein interactions. The best characterized TPR proteins are those found associated to Hsp90 in steroid receptor complexes. In previous works, our laboratory demonstrated that the main TPR-domain immunophilins FKBP51 and FKBP52 regulate the activity of the glucocorticoid receptor (GR) in a competitive fashion with other coexisting TPR proteins, such as PP5, SGT1α and 14-3-3σ. In this work, the study was extended to the androgen receptor (AR).