Artículo
Antimicrobial and Antioxidant Activities of Gentianella multicaulis Collected on the Andean Slopes of San Juan Province, Argentina
Lima, Beatriz Viviana
; Sánchez, Marianela
; Luna, Lorena Celina
; Agüero, María Belén
; Zacchino, Susana Alicia Stella; Filippa, Eva María; Palermo, Jorge Alejandro
; Tapia, Aníbal Alejandro; Feresin, Gabriela Egly






Fecha de publicación:
01/2012
Editorial:
Verlag der Zeitschrift für Naturforschung
Revista:
Zeitschrift für Naturforschung C. A Journal of Biosciences
ISSN:
0939-5075
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as ‘nencia’, is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaulis extracts and structural elucidation of the main compounds responsible for the antifungal and free radical scavenging activities were performed. The extracts had strong free radical scavenging effects in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (45 – 93% at 10 μg/mL) and ferric-reducing antioxidant power (FRAP) assay at 200 μg/mL. Demethylbellidifolin (4) had high antioxidant activity in the DPPH and FRAP assay. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were moderately inhibited by the different extracts (MIC values of 125 – 250 μg/mL). Demethylbellidifolin (4), bellidifolin (5), and isobellidifolin (6) showed an antifungal effect (MIC values of 50 μg/mL), while swerchirin (3) was less active with a MIC value of 100 μg/mL. In addition, oleanolic acid (1) and ursolic acid (2) were also isolated. These fi ndings demonstrate that Gentianella multicaulis collected in the mountains of the Province of San Juan, Argentina, is an important source of compounds with antifungal and antioxidant activities.
Palabras clave:
GENTIANELLA MULTICAULIS
,
TRYCHOPHYTON SPP:
,
ANTIOXIDANT ACTIVITY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - SAN JUAN)
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Lima, Beatriz Viviana; Sánchez, Marianela; Luna, Lorena Celina; Agüero, María Belén; Zacchino, Susana Alicia Stella; et al.; Antimicrobial and Antioxidant Activities of Gentianella multicaulis Collected on the Andean Slopes of San Juan Province, Argentina; Verlag der Zeitschrift für Naturforschung; Zeitschrift für Naturforschung C. A Journal of Biosciences; 67; 1-2; 1-2012; 29-38
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