Muscle trophism after testosterone treatment in the Wobbler mouse, a spontaneous model for amyotrophic lateral sclerosis (ALS)

Abstract

Patients suffering amyotrophic lateral sclerosis (ALS) present muscle atrophy in upper and lower limbs and difficulties in swallowing and dysarthria in association to motoneuron degeneration. Wobbler mice (WR) ar animal models of ALS showing selective loss of motoneurons, astrocytosis and microgliosis in the ventral horn of the cervical spinal cord, brain stem and motor cortex.