Artículo
Total synthesis of naturally occurring 5,6,7- and 5,7,8-trioxygenated coumarins
Maes, Dominick; Riveiro, Maria Eugenia
; Shayo, Carina Claudia
; Davio, Carlos Alberto
; Debenedetti, Silvia Laura; De Kimpe, Norbert
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Fecha de publicación:
2008
Editorial:
Elsevier
Revista:
Tetrahedron
ISSN:
0040-4020
e-ISSN:
0040-4020
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
The synthesis of five naturally occurring polyoxygenated coumarins is described. It concerns two 5,6,7-trioxygenated coumarins, i.e., 6-hydroxy-5,7-dimethoxycoumarin (fraxinol) 1 and 5,6,7-trimethoxycoumarin 2, and three 5,7,8-trioxygenated coumarins, i.e., 8-hydroxy-5,7-dimethoxycoumarin (leptodactylone) 3, 5,7,8-trimethoxycoumarin 4 and 8-(3-methyl-2-butenyloxy)-5,7-dimethoxycoumarin (artanin) 5. Key feature of the synthetic pathway is the synthesis of suitable tetraoxygenated benzaldehydes, which are then converted to the corresponding coumarins via a Wittig reaction.
Palabras clave:
Coumarins
,
Total Synthesis
,
Wittig Reaction
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Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Maes, Dominick; Riveiro, Maria Eugenia; Shayo, Carina Claudia; Davio, Carlos Alberto; Debenedetti, Silvia Laura; et al.; Total synthesis of naturally occurring 5,6,7- and 5,7,8-trioxygenated coumarins; Elsevier; Tetrahedron; 64; 19; -1-2008; 4438-4443
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