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Artículo

First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence

Gonzalez, Paula ValeriaIcon ; Loureiro, Aline C.; Gómez Bravo, Andrea; Castillo, Paola MarcelaIcon ; Espinosa, Manuel; Gil, José FernandoIcon ; Martins, Ademir J.; Harburguer, Laura VanesaIcon
Fecha de publicación: 08/2024
Editorial: BioMed Central
Revista: Parasites and Vectors
ISSN: 1756-3305
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Aedes aegypti (L.) is the main vector of dengue, yellow fever, Zika, and chikungunya viruses in many parts of the world, impacting millions of people worldwide each year. Insecticide-based interventions have been effective in controlling Aedes mosquito populations for several years, but in recent times, resistance to these compounds has developed, posing a global threat to the control of this mosquito. Ovitraps were used to collect A. aegypti eggs in the cities of Tartagal and San Ramón de la Nueva Orán (Salta), Puerto Iguazú (Misiones), and Clorinda (Formosa). World Health Organization (WHO)-impregnated papers with the discriminating concentration (DC) of permethrin, 5X, 10X and pirimiphos methyl were used for the toxicological bioassays. We also genotyped each sample for the three kdr single nucleotide polymorphisms (SNP): V410L, V1016I, and F1534C in individual TaqMan quantitative PCR (qPCR) reactions. All investigated A. aegypti populations were highly resistant to permethrin, as the mortality percentage with the permethrin 10×DC remained below 98%. However, all populations were 100% susceptible to pirimiphos-methyl. Kdr genotyping demonstrated the presence of the V410L mutation for the first time in Argentina in all the populations studied. A prevalence of the triple mutant genotype (LL + II + CC) was observed in the northeastern cities of Clorinda (83.3%) and Puerto Iguazú (55.6%). This study demonstrates for the first time the presence and intensity of resistance to permethrin in different populations from Argentina, and correlates the observed phenotype with the presence of kdr mutations (genotype).
Palabras clave: Aedes aegypti , V410L kdr mutation , Toxicologic
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/257463
URL: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-024-06405-
DOI: http://dx.doi.org/10.1186/s13071-024-06405-3
Colecciones
Articulos(INENCO)
Articulos de INST.DE INVEST.EN ENERGIA NO CONVENCIONAL
Articulos(UNIDEF)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO ESTRATEGICOS PARA LA DEFENSA
Citación
Gonzalez, Paula Valeria; Loureiro, Aline C.; Gómez Bravo, Andrea; Castillo, Paola Marcela; Espinosa, Manuel; et al.; First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence; BioMed Central; Parasites and Vectors; 17; 1; 8-2024; 1-10
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