Artículo
A BDNF sensitive mechanism is involved in the fear memory resulting from the interaction between stress and the retrieval of an established trace
Fecha de publicación:
05/2013
Editorial:
Cold Spring Harbor Lab Press
Revista:
Learning & Memory (cold Spring Harbor, N.y.)
ISSN:
1072-0502
e-ISSN:
1549-5485
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The present study investigates the fear memory resulting from the interaction of a stressful experience and the retrieval of an established fear memory trace. Such a combination enhanced both fear expression and fear retention in adult Wistar rats. Likewise, midazolam intra-basolateral amygdala (BLA) infusion prior to stress attenuated the enhancement of fear memory thus suggesting the involvement of a stress-induced reduction of the GABAergic transmission in BLA in the stress-induced enhancing effect. It has been suggested that, unlike the immediate-early gene Zif268 which is related to the reconsolidation process, the expression of hippocampal brain-derived neurotrophic factor (BDNF) is highly correlated with consolidation. We therefore evaluate the relative contribution of these two neurobiological processes to the fear memory resulting from the above-mentioned interaction. Intra-dorsal hippocampus (DH) infusions of either the antisense Zif268 or the inhibitor of the protein degradation (Clasto-Lactacystin β-Lactone), suggested to be involved in the retrieval-dependent destabilization process, did not affect the resulting contextual memory. In contrast, the knockdown of hippocampal BDNF mitigated the stress-induced facilitating influence on fear retention. In addition, the retrieval experience elevated BDNF level in DH at 60 min after recall exclusively in stressed animals. These findings suggest the involvement of a hippocampal BDNF sensitive mechanism in the stress-promoting influence on the fear memory following retrieval.
Palabras clave:
Bdnf
,
Fear Memory
,
Stress
,
Retrieval
Archivos asociados
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Identificadores
Colecciones
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Citación
Giachero, Marcelo; Bustos, Silvia Gabriela; Calfa, Gaston Diego; Molina, Víctor Alejandro; A BDNF sensitive mechanism is involved in the fear memory resulting from the interaction between stress and the retrieval of an established trace; Cold Spring Harbor Lab Press; Learning & Memory (cold Spring Harbor, N.y.); 20; 5-2013; 245-255
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