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dc.contributor.author Paz, Maria Constanza
dc.contributor.author Marchese, Natalia Andrea
dc.contributor.author Cancela, Liliana Marina
dc.contributor.author Bregonzio Diaz, Claudia
dc.date.available 2017-10-02T21:40:40Z
dc.date.issued 2013-06
dc.identifier.citation Paz, Maria Constanza; Marchese, Natalia Andrea; Cancela, Liliana Marina; Bregonzio Diaz, Claudia; Angiotensin II AT1 receptors are involved in neuronal activation induced by amphetamine in a two-injection protocol; Hindawi Publishing Corporation; BioMed Research International; 2013; 6-2013; 1-10; 534817
dc.identifier.issn 2314-6133
dc.identifier.uri http://hdl.handle.net/11336/25695
dc.description.abstract It was already found that Ang II AT1 receptors are involved in the neuroadaptative changes induced by a single exposure to amphetamine, and such changes are related to the development of behavioral and neurochemical sensitization. The induction of the immediately early gene c-fos has been used to define brain activated areas by amphetamine. Our aim was to evaluate the participation of AT1 receptors in the neuronal activation induced by amphetamine sensitization. The study examined the c-fos expression in mesocorticolimbic areas induced by amphetamine challenge (0.5 mg/kg i.p) in animals pretreated with candesartan, a selective AT1 receptor blocker (3 mg/kg p.o × 5 days), and amphetamine (5 mg/kg i.p) 3 weeks before the challenge. Increased c-fos immunoreactivity was found in response to the amphetamine challenge in the dorsomedial caudate-putamen and nucleus accumbens, and both responses were blunted by the AT1 receptor blocker pretreatment. In the infralimbic prefrontal cortex, increased c-fos immunoreactivity was found in response to amphetamine and saline challenge, and both were prevented by the AT1 receptor blocker. No differences were found neither in ventral tegmental area nor prelimbic cortex between groups. Our results indicate an important role for brain Ang II in the behavioral and neuronal sensitization induced by amphetamine.
dc.format application/pdf
dc.language.iso eng
dc.publisher Hindawi Publishing Corporation
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject AT1 RECEPTORS
dc.subject AMPHETAMINE
dc.subject TWO-INJECTION PROTCOL
dc.subject ANGIOTENSIN
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Angiotensin II AT1 receptors are involved in neuronal activation induced by amphetamine in a two-injection protocol
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-10-02T19:06:58Z
dc.identifier.eissn 2314-6141
dc.journal.volume 2013
dc.journal.pagination 1-10; 534817
dc.journal.pais Egipto
dc.journal.ciudad El Cairo
dc.description.fil Fil: Paz, Maria Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil Fil: Marchese, Natalia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.journal.title BioMed Research International
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2013/534817
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2013/534817/


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    Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)