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dc.contributor.author
Romero, Jorge Miguel  
dc.date.available
2025-03-19T13:21:25Z  
dc.date.issued
2024-11  
dc.identifier.citation
Romero, Jorge Miguel; Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase; Elsevier Science Inc.; Archives of Biochemistry and Biophysics; 761; 11-2024; 1-11  
dc.identifier.issn
0003-9861  
dc.identifier.uri
http://hdl.handle.net/11336/256592  
dc.description.abstract
ABSTRACT Human triosephosphate isomerase G122R, also known as TPI-Manchester, is a thermolabile variant detected in a screening of more than 3400 individuals from a population in Ann Arbor, Michigan. Here, the crystallographic structure of G122R was solved to determine the molecular basis of its thermal stability. Structural analysis revealed an increase in the flexibility of residues at the dimer interface, even though R122 is about 20 Å away, suggesting that long-range electrostatic interactions may play a key role in the mutation effect.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science Inc.  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
TPI  
dc.subject
CRISTALLIZATION  
dc.subject
STABILITY  
dc.subject
FLEXIBILITY  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2025-03-18T13:33:55Z  
dc.journal.volume
761  
dc.journal.pagination
1-11  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Romero, Jorge Miguel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina  
dc.journal.title
Archives of Biochemistry and Biophysics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0003986124002789  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.abb.2024.110156  

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