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dc.contributor.author
Chiarandini Fiore, Jessica Paola
dc.contributor.author
Fanelli, Silvia Laura
dc.contributor.author
de Ferreyra, Elida C.
dc.contributor.author
Castro, Jose Alberto
dc.date.available
2017-10-02T15:49:46Z
dc.date.issued
2008-11
dc.identifier.citation
Chiarandini Fiore, Jessica Paola; Fanelli, Silvia Laura; de Ferreyra, Elida C.; Castro, Jose Alberto; Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects; Taylor & Francis; Nutrition And Cancer; 60; 6; 11-2008; 784-791
dc.identifier.issn
0163-5581
dc.identifier.uri
http://hdl.handle.net/11336/25566
dc.description.abstract
Cisplatin (CisPt) is an effective chemotherapeutic agent against several human cancers, but it produces important nephrotoxicity, leukopenia, and mortality. In this work, we report initial results on the potential ability of diallyl disulfide (DADS) to block these toxicities without compromising chemotherapy. Male Sprague Dawley rats were used (control, DADS, CisPt, and CisPt/DADS). CisPt was administered sc as a single dose (10.5 mg/kg) in saline. DADS was given daily intragastrically in olive oil (292.5 mg/kg) 1 h before CisPt administration the first day and 146.25 mg/kg during the next 3 days. The animals were sacrificed at the fifth day after CisPt administration. DADS significantly decreased CisPt-induced nephrotoxicity as evaluated by histology and by seric urea (CisPt: 11.05 ± 3.59; CisPt/DADS: 6.53 ± 1.74) and creatinine (CisPt: 24.74 ± 3.03; CisPt/DADS: 14.83 ± 2.07). DADS also decreased leukopenia (CisPt: 13.5% and CisPt/DADS: 43.4% respect the control), and mortality (CisPt: 50%; CisPt/DADS: 29%). DADS showed ability to interact with reactive oxygen species (H2O2, hydroperoxides, OH•) and with iron. DADS treatment does not change Platinum levels in kidney (CisPt: 15.2 ± 5.1; CisPt/DADS: 13.9 ± 4.5). Because DADS is known to inhibit cellular replication and to promote apoptosis of tumor cells, results suggest that DADS merit to be tested as a potential coadjuvant of CisPt chemotherapy in tumor-bearing animals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Diallyl Disulfide
dc.subject
Cisplatin
dc.subject
Nephrotoxicity
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-26T18:59:41Z
dc.journal.volume
60
dc.journal.number
6
dc.journal.pagination
784-791
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Chiarandini Fiore, Jessica Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
dc.description.fil
Fil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
dc.description.fil
Fil: de Ferreyra, Elida C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
dc.description.fil
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
dc.journal.title
Nutrition And Cancer
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/01635580802100869
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/01635580802100869
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