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dc.contributor.author
Lopez Bergami, Pablo Roberto
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dc.contributor.author
Fitchmann, B
dc.contributor.author
Ronai, Ze´ev
dc.date.available
2017-10-02T15:41:58Z
dc.date.issued
2008
dc.identifier.citation
Lopez Bergami, Pablo Roberto; Fitchmann, B; Ronai, Ze´ev; Understanding signaling cascades in melanoma; Wiley; Photochemistry and Photobiology; 84; 2; -1-2008; 289-306
dc.identifier.issn
0031-8655
dc.identifier.uri
http://hdl.handle.net/11336/25563
dc.description.abstract
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control, metabolism, motility and the ability to escape cell death programs. Here we review the major signaling pathways currently known to be deregulated in melanoma with an implication to its development and progression. Among these pathways are Ras, B-Raf, MEK, PTEN, phosphatidylinositol-3 kinase (PI3Ks) and Akt which are constitutively activated in a significant number of melanoma tumors, in most cases due to genomic change. Other pathways discussed in this review include the [Janus kinase/signal transducer and activator of transcription (JAK/STAT), transforming growth factor-beta pathways which are also activated in melanoma, although the underlying mechanism is not yet clear. As a paradigm for remodeled signaling pathways, melanoma also offers a unique opportunity for targeted drug development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melanoma
dc.subject
Signal Transduction
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Understanding signaling cascades in melanoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-25T18:30:15Z
dc.identifier.eissn
1751-109
dc.journal.volume
84
dc.journal.number
2
dc.journal.pagination
289-306
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Lopez Bergami, Pablo Roberto. Sanford-burnham Medical Research Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Fitchmann, B. Sanford-burnham Medical Research Institute; Estados Unidos
dc.description.fil
Fil: Ronai, Ze´ev. Sanford-burnham Medical Research Institute; Estados Unidos
dc.journal.title
Photochemistry and Photobiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2007.00254.x/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1751-1097.2007.00254.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874067/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/18086245
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