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Artículo

GABAB receptors in neuroendocrine regulation

Lux, Victoria Adela R.Icon ; Bianchi, Maria SilviaIcon ; Catalano, Paolo NicolásIcon ; Libertun, CarlosIcon
Fecha de publicación: 09/2008
Editorial: Springer/Plenum Publishers
Revista: Cellular and Molecular Neurobiology
ISSN: 0272-4340
e-ISSN: 1573-6830
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Gamma-amino butyric acid (GABA), in addition to being a metabolic intermediate and the main inhibitory neurotransmitter in the synaptic cleft, is postulated as a neurohormone, a paracrine signaling molecule, and a trophic factor. It acts through pre- and post-synaptic receptors, named GABA(A) and GABA(C) (ionotropic receptors) and GABA(B) (metabotropic receptor). Here we reviewed the participation of GABA(B) receptors in the regulation of the hypothalamic-pituitary-gonadal axis, using physiological, biochemical, and pharmacological approaches in rats, as well as in GABA(B1) knock-out mice, that lack functional GABA(B) receptors. Our general conclusion indicates that GABA(B )receptors participate in the regulation of pituitary hormone secretion acting both in the central nervous system and directly on the gland. PRL and gonadotropin axes are affected by GABA(B) receptor activation, as demonstrated in the rat and also in the GABA(B1) knock-out mouse. In addition, hypothalamic and pituitary GABA(B) receptor expression is modulated by steroid hormones. GABA participation in the brain control of pituitary secretion through GABA(B) receptors depends on physiological conditions, being age and sex critical factors.These results indicate that patients receiving GABA(B) agonists/antagonists should be monitored for possible endocrine side effects.
Palabras clave: Gabab , Receptors , Hormones , Gabab1 Ko Mice
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/25547
URL: https://link.springer.com/article/10.1007/s10571-008-9263-4
DOI: http://dx.doi.org/10.1007/s10571-008-9263-4
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Lux, Victoria Adela R.; Bianchi, Maria Silvia; Catalano, Paolo Nicolás; Libertun, Carlos; GABAB receptors in neuroendocrine regulation; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 28; 6; 9-2008; 803-817
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