D−− phenotype caused by a novel RHCE null allele

A new hybrid RHCE null allele, denoted here RHCE*ce(48C)-D(3-7)-CE anddesignated by the ISBT as RHCE*01N.16, was found to be responsible for a D- -phenotype showing exalted D antigen expression. The loss of native RhCE proteinsinteractions may relieve some steric hindrance and increase D epitopes presentation atthe membrane surface resulting in an overexpression of the D antigen4. This is anunusual phenotype in all populations.

Palabras clave: RHCE , NULL , ISBT

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/255438

URL: https://onlinelibrary.wiley.com/doi/full/10.1111/trf.17698

DOI: http://dx.doi.org/10.1111/trf.17698

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Articulos(IDICER)
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO

Citación

Principi, Cintia Soledad; Trucco Boggione, Carolina; Ensinck, María Alejandra; Posner, Victoria Maria; Luján Brajovich, Melina Eliana; et al.; D−− phenotype caused by a novel RHCE null allele; Wiley Blackwell Publishing, Inc; Transfusion; 64; 2; 12-2023; 1-3

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