Evento

A glycosylation-dependent pathway of non-canonical VEGFR2 activation links tumor hypoxia to vascular remodeling and immunity

Croci Russo, Diego OmarIcon ; Salatino, MarianaIcon ; Ouyang, J.; Rubinstein, N.; Mascanfroni, Ivan DaríoIcon ; Cerliani, Juan PabloIcon ; Ilarregui, Juan MartinIcon ; Sundblad, VictoriaIcon ; Toscano, Marta AliciaIcon ; Domaica, Carolina InesIcon ; Dergan Dylon, Leonardo SebastianIcon ; Croci, M. C.; Albini, A.; Shipp, M. A; Rabinovich, Gabriel AdriánIcon
Colaboradores: Cobb, Brian A.; Rabinovich, Gabriel AdriánIcon ; van Kooyk, Ivette
Tipo del evento: Simposio
Nombre del evento: Keystone Symposia: New Frontiers at the Interface of Immunity and Glycobiology
Fecha del evento: 06/03/2011
Institución Organizadora: Keystone Symposia on Molecular and Cellular Biology;
Título del Libro: Keystone Symposia: New Frontiers at the Interface of Immunity and Glycobiology
Editorial: Keystone Symposia
Idioma: Inglés
Clasificación temática:

Resumen

The mechanisms linking tumor hypoxia, neovascularization and immunity are poorly understood. Resistance to VEGF-targeted antiangiogenic therapies suggests the contribution ol noncanonicaI pathways to hypoxia-driven neovascularization. We previously demonstrated an essential role ol galectin-1 (Gal-1) in the control of tumor growth by favoring tumor-immune escape. The present study was conducted to elucidate whether Gal1-glycan lattices link tumor hypoxia a to neovasculanzation and to Investigate whether disruption ol these lattices using an anti Gal1mAb, may contribute to remodeling tumor vascular networks and stimulation of antitumor immune responses.
Palabras clave: GALECTIN-1 , VEGFR2 , ANGIOGENESIS
 
Archivos asociados
Tamaño: 1.812Mb
Formato: PDF
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Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/255066
URL: https://www.rsc.org/events/detail/15475/keystone-symposia-new-frontiers-at-the-i
URL: http://keystonesymposia.org/Meetings/MeetingFlyer.cfm?MeetingID=1106
Colecciones
Eventos(IBYME)
Eventos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
A glycosylation-dependent pathway of non-canonical VEGFR2 activation links tumor hypoxia to vascular remodeling and immunity; Keystone Symposia: New Frontiers at the Interface of Immunity and Glycobiology; Lake Louise; Canadá; 2011; 69-69
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