Artículo
Physiological and pathological aspects of epididymal sperm maturation
Weigel Muñoz, Mariana
; Cohen, Debora Juana
; Da Ros, Vanina Gabriela
; Gonzalez, Soledad N.; Rebagliati Cid, Abril; Sulzyk, Valeria
; Cuasnicu, Patricia Sara





Fecha de publicación:
12/2024
Editorial:
Elsevier Science
Revista:
Molecular Aspects Of Medicine
ISSN:
0098-2997
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In mammals, sperm that leave the testes are nonfunctional and require a complex post-testicular maturation process to acquire their ability to recognize and fertilize the egg. The crucial maturation changes that provide sperm their fertilizing capability occur while passing through the epididymis. Due to the widespread use of assisted reproductive technologies to address male infertility, there has been a significant decrease in research focusing on the mechanisms underlying the maturation process over the past decades. Considering that up to 40% of male infertility is idiopathic and could be reflecting sperm maturation defects, the study of post-testicular sperm maturation will clearly contribute to a better understanding of the causes of male infertility and to the development of both new approaches to maturing sperm in vitro and safer male contraceptive methods. Based on this, the present review focuses on the physiopathology of the epididymis as well as on current approaches under investigation to improve research in sperm maturation and as potential therapeutic options for male infertility.
Palabras clave:
EPIDIDYMIS
,
SPERM
,
CONTRACEPTION
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Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Weigel Muñoz, Mariana; Cohen, Debora Juana; Da Ros, Vanina Gabriela; Gonzalez, Soledad N.; Rebagliati Cid, Abril; et al.; Physiological and pathological aspects of epididymal sperm maturation; Elsevier Science; Molecular Aspects Of Medicine; 100; 101321; 12-2024; 1-15
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