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dc.contributor.author
Martínez, S. M.
dc.contributor.author
Simonella, Lucio Esteban
dc.contributor.author
Hansen, C.
dc.contributor.author
Rivolta, S.
dc.contributor.author
Cancela, Liliana Marina
dc.contributor.author
Virgolini, Miriam Beatriz
dc.date.available
2017-09-29T19:29:09Z
dc.date.issued
2013-05
dc.identifier.citation
Martínez, S. M.; Simonella, Lucio Esteban; Hansen, C.; Rivolta, S.; Cancela, Liliana Marina; et al.; Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline; Sage Publications Ltd; Human and Experimental Toxicoloxy; 32; 5; 5-2013; 449-463
dc.identifier.issn
0960-3271
dc.identifier.uri
http://hdl.handle.net/11336/25463
dc.description.abstract
Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring d-aminolevulinic acid dehydratase (d-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 + 0.30 mg/dl. Enzymatic d-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased d-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sage Publications Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lead Exposure
dc.subject
Children
dc.subject
Biomarkers
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Low Socio-Economic Status
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Ética Médica
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-28T19:03:48Z
dc.journal.volume
32
dc.journal.number
5
dc.journal.pagination
449-463
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Martínez, S. M.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Simonella, Lucio Esteban. Universidad Nacional de Cordoba. Facultad de Ciencias Exactas Fisicas y Naturales. Centro de Investigaciones Geoquímicas y Procesos de Superficie; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hansen, C.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Rivolta, S.. Provincia de Córdoba. Hospital de Niños de la Santísima Trinidad; Argentina
dc.description.fil
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.journal.title
Human and Experimental Toxicoloxy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0960327112454893
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0960327112454893


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  • Articulos(IFEC) [85]
    Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA

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