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dc.contributor.author Martínez, S. M.
dc.contributor.author Simonella, Lucio Esteban
dc.contributor.author Hansen, C.
dc.contributor.author Rivolta, S.
dc.contributor.author Cancela, Liliana Marina
dc.contributor.author Virgolini, Miriam Beatriz
dc.date.available 2017-09-29T19:29:09Z
dc.date.issued 2013-05
dc.identifier.citation Martínez, S. M.; Simonella, Lucio Esteban; Hansen, C.; Rivolta, S.; Cancela, Liliana Marina; et al.; Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline; Sage Publications Ltd; Human and Experimental Toxicoloxy; 32; 5; 5-2013; 449-463
dc.identifier.issn 0960-3271
dc.identifier.uri http://hdl.handle.net/11336/25463
dc.description.abstract Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring d-aminolevulinic acid dehydratase (d-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 + 0.30 mg/dl. Enzymatic d-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased d-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.
dc.format application/pdf
dc.language.iso eng
dc.publisher Sage Publications Ltd
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Lead exposure
dc.subject Children
dc.subject Biomarkers
dc.subject Low socio-economic status
dc.subject.classification Ética Médica
dc.subject.classification Ciencias de la Salud
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-09-28T19:03:48Z
dc.journal.volume 32
dc.journal.number 5
dc.journal.pagination 449-463
dc.journal.pais Reino Unido
dc.description.fil Fil: Martínez, S. M.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil Fil: Simonella, Lucio Esteban. Universidad Nacional de Cordoba. Facultad de Ciencias Exactas Fisicas y Naturales. Centro de Investigaciones Geoquímicas y Procesos de Superficie; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Hansen, C.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil Fil: Rivolta, S.. Provincia de Córdoba. Hospital de Niños de la Santísima Trinidad; Argentina
dc.description.fil Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.journal.title Human and Experimental Toxicoloxy
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0960327112454893
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0960327112454893


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    Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)