Two New Furanoeremophilanes from Senecio santelisis

Abstract

From an Argentine collection of Senecio santelisis Phil., the new furanoeremophilanoids, (10βH)-6β-acetoxy-1α-hydroxyfuranoeremophilan-9-one (1) and (10βH)-1α-hydroxy-6β-(propanoyloxy)furanoeremophilan-9-one (2), together with the known (10αH)-6β-acetoxy-1α-hydroxyfuranoeremophilan-9-one (3), (10αH)-1α,6β-diacetoxyfuranoeremophilan-9-one (4), and (10αH)-1α-hydroxy-6β-(propanoyloxy)furanoeremophilan-9-one (5) were isolated. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl3 Extract and pure compounds were evaluated for their antifungal activity. Compound 5 exhibited remarkable mycelial growth inhibition against B. cinerea with an IC50 value of 21.4 μg/ml.