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Artículo

Chemometric tools improving the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode array detection

Gil García, M. D.; Cañada Cañada, F.; Culzoni, Maria JuliaIcon ; Vera Candioti, LucianaIcon ; Siano, Gabriel GermanIcon ; Goicoechea, Hector CasimiroIcon ; Martínez Galera, M.
Fecha de publicación: 07/2009
Editorial: Elsevier Science
Revista: Journal Of Chromatography - A
ISSN: 0021-9673
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

An analytical method for the simultaneous determination of seven non-steroidal anti-inflammatory drugs (naproxen, ketoprofen, diclofenac, piroxicam, indomethacin, sulindac and diflunisal) and the anticonvulsant carbamazepine in river and wastewater is reported. The method involves pre-concentration and clean-up by solid-phase microextraction using polydimethylsiloxane/divinylbenzene fibers, followed by liquid chromatography with diode array detection analysis. Owing to the fact that river water samples did not contain interferences and no sensitivity changes due to sample matrix were observed, external calibration was implemented. Standardization was also applied in order to carry out the prediction step by preparing only two diluted standards that were subjected to the pre-concentration step and a set of standards prepared in solvent. For the analysis of wastewater samples, in contrast, it was necessary to implement standard addition calibration in combination with the multivariate curve resolution-alternating least squares (MCR-ALS) algorithm, which allowed us to overcome matrix effect and exploit the second order advantage. Recoveries ranging from 72% to 125% for all pharmaceuticals proved the accuracy of the proposed method in river water samples. On the other hand, wastewater sample recoveries ranged from 83% to 140% for all pharmaceuticals, showing an acceptable performance – considering this sample contains no modeled interferences.
Palabras clave: Pharmaceuticals , Solid-Phase Microextraction , Liquid Chromatograpy-Diode Array , Detection , River Water , Wastewater , Second Order Advantage
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/25440
URL: http://www.sciencedirect.com/science/article/pii/S0021967309008206
DOI: http://dx.doi.org/10.1016/j.chroma.2009.05.073
Colecciones
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
Gil García, M. D.; Cañada Cañada, F.; Culzoni, Maria Julia; Vera Candioti, Luciana; Siano, Gabriel German; et al.; Chemometric tools improving the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode array detection; Elsevier Science; Journal Of Chromatography - A; 1216; 29; 7-2009; 5489-5496
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