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dc.contributor.author
Celada, Pau
dc.contributor.author
Lladó Pelfort, L.
dc.contributor.author
Santana, N.
dc.contributor.author
Kargieman, Lucila
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dc.contributor.author
Troyano Rodriguez, Eva
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Riga, M. S.
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Artigas, Francesc
dc.date.available
2017-09-29T16:23:45Z
dc.date.issued
2013-11
dc.identifier.citation
Celada, Pau; Lladó Pelfort, L.; Santana, N.; Kargieman, Lucila; Troyano Rodriguez, Eva; et al.; Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action; Cambridge University Press; International Journal Of Neuropsychopharmacology; 16; 10; 11-2013; 2145-2163
dc.identifier.issn
1461-1457
dc.identifier.uri
http://hdl.handle.net/11336/25424
dc.description.abstract
Non-competitive NMDA receptor antagonists are widely used as pharmacological models of schizophrenia due to their ability to evoke the symptoms of the illness. Likewise, serotonergic hallucinogens, acting on 5-HT2A receptors, induce perceptual and behavioural alterations possibly related to psychotic symptoms. The neurobiological basis of these alterations is not fully elucidated. Data obtained in recent years revealed that the NMDA receptor antagonist phencyclidine (PCP) and the serotonergic hallucinogen 1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane; DOI) produce a series of common actions in rodent prefrontal cortex (PFC) that may underlie psychotomimetic effects. Hence, both agents markedly disrupt PFC function by altering pyramidal neuron discharge (with an overall increase) and reducing the power of low frequency cortical oscillations (LFCO; < 4 Hz). In parallel, PCP increased c-fos expression in excitatory neurons of various cortical areas, the thalamus and other subcortical structures, such as the amygdala. Electrophysiological studies revealed that PCP altered similarly the function of the centromedial and mediodorsal nuclei of the thalamus, reciprocally connected with PFC, suggesting that its psychotomimetic properties are mediated by an alteration of thalamocortical activity (the effect of DOI was not examined in the thalamus). Interestingly, the observed effects were prevented or reversed by the antipsychotic drugs clozapine and haloperidol, supporting that the disruption of PFC activity is intimately related to the psychotomimetic activity of these agents. Overall, the present experimental model can be successfully used to elucidate the neurobiological basis of schizophrenia symptoms and to examine the potential antipsychotic activity of new drugs in development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
5-Ht Receptors
dc.subject
Antipsychotic Drugs
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Nmda Receptors
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Prefrontal Cortex
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Thalamus
dc.subject.classification
Ética Médica
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-28T18:11:49Z
dc.journal.volume
16
dc.journal.number
10
dc.journal.pagination
2145-2163
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Celada, Pau. Consejo Superior de Investigaciones Científicas; España. Centro de Investigación Biomédica en Red de Salud Mental; España. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España
dc.description.fil
Fil: Lladó Pelfort, L.. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Santana, N.. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Kargieman, Lucila. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España. Consejo Superior de Investigaciones Científicas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Troyano Rodriguez, Eva. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Riga, M. S.. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Artigas, Francesc. Consejo Superior de Investigaciones Científicas; España. Institut d'Investigacions Biomèdiques de Barcelona. Department of Neurochemistry and Neuropharmacology; España
dc.journal.title
International Journal Of Neuropsychopharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S1461145713000643
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145713000643
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