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dc.contributor.author
Radwan, Asma
dc.contributor.author
Ebert, Sandro
dc.contributor.author
Amar, Andrea Mariela
dc.contributor.author
Münnemann, Kerstin
dc.contributor.author
Wagner, Manfred
dc.contributor.author
Amidon, Gordon L.
dc.contributor.author
Langguth, Peter
dc.date.available
2017-09-28T21:05:19Z
dc.date.issued
2013-04
dc.identifier.citation
Radwan, Asma; Ebert, Sandro; Amar, Andrea Mariela; Münnemann, Kerstin; Wagner, Manfred; et al.; Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms; American Chemical Society; Molecular Pharmaceutics; 10; 6; 4-2013; 2283-2290
dc.identifier.issn
1543-8384
dc.identifier.uri
http://hdl.handle.net/11336/25393
dc.description.abstract
Much interest has been expressed in this work on the role of water diffusivity in the release media as a new parameter for predicting drug release. NMR was used to measure water diffusivity in different media varying in their osmolality and viscosity. Water self-diffusion coefficients in sucrose, sodium chloride, and polymeric hydroxypropyl methylcellulose (HPMC) solutions were correlated with water uptake, disintegration, and drug release rates from trospium chloride immediate release tablets. The water diffusivity in sucrose solutions was significantly reduced compared to polymeric HPMC and molecular sodium chloride solutions. Water diffusivity was found to be a function of sucrose concentration in the media. Dosage form disintegration and drug release was to be affected by water diffusivity in these systems. This observation can be explained by hydrogen bonding formation between sugar molecules, an effect which was not expressed in sodium chloride solutions of equal osmolality. Water diffusivity and not media osmolality in general need to be considered to predict the effect of disintegration and dissolution media on drug release. Understanding the relevance of water diffusivity for disintegration and dissolution will lead to better parametrization of dosage form behavior in gastrointestinal (GI) aqueous and semisolid media.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tablets
dc.subject
Biopredictive Media
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Dissolution
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Biopharmaceutic Prediction
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Diffusion Coefficient
dc.subject.classification
Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-28T19:02:51Z
dc.journal.volume
10
dc.journal.number
6
dc.journal.pagination
2283-2290
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Radwan, Asma. University Mainz. Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg; Alemania
dc.description.fil
Fil: Ebert, Sandro. Max Planck Institute for Polymer Research; Alemania
dc.description.fil
Fil: Amar, Andrea Mariela. Max Planck Institute for Polymer Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; Alemania
dc.description.fil
Fil: Wagner, Manfred. Max Planck Institute for Polymer Research; Alemania
dc.description.fil
Fil: Amidon, Gordon L.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Langguth, Peter. University Mainz. Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg; Alemania
dc.journal.title
Molecular Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/mp3006209
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/mp3006209
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