Capítulo de Libro
Molecular Pharmacology of the Youngest Member of the Nuclear Receptor Family: The Mineralocorticoid Receptor
Título del libro: Nuclear Receptors: The Art and Science of Modulator Design and Discovery
Galigniana, Mario Daniel

Otros responsables:
Badr, Mostafa Z.
Fecha de publicación:
2021
Editorial:
Springer Nature Switzerland AG
ISBN:
978-3-030-78315-0
Idioma:
Inglés
Clasificación temática:
Resumen
The mineralocorticoid receptor (MR) was the last member of the nuclear receptor superfamily to evolve. It is responsible for the maintenance of the water and salt homeostasis. Like most ligand-activated transcription factors of this superfamily, it is activated by ligand binding. The MR exists as a large heterocomplex assembled with the heat-shock protein of 90-kDa chaperone, Hsp90, and other associated chaperones and cochaperones. The composition of this heterocomplex is affected by the nature of the bound steroid. MR biological responses are also affected by the redox status of the cell or due to protein phosphorylation. In this chapter, the conformational requirements of the steroid to become an optimal MR ligand, the role of the Hsp90-based heterocomplex, and the influence of MR modifications by oxidation and phosphorylation is discussed. These properties are analyzed in the light of the relevance of this nuclear receptor as a key pharmacological target for disorders mostly related to the hydroelectrolytic homeostasis.
Palabras clave:
MR
,
ALDOSTERONE
,
SODIUM RETENTION
,
HYPERTENSION
Archivos asociados
Licencia
Identificadores
Colecciones
Capítulos de libros(IBYME)
Capítulos de libros de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Capítulos de libros de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Galigniana, Mario Daniel; Molecular Pharmacology of the Youngest Member of the Nuclear Receptor Family: The Mineralocorticoid Receptor; Springer Nature Switzerland AG; 2021; 10-24
Compartir
Altmétricas