Evento

Development of an hydroxymethylglutharyl-coenzyme a reductase (hmgcr) overexpression system for the study of reprogramming to stem-like states in human breast cancer

Marks, Maria PaulaIcon ; Giménez, Carla AlejandraIcon ; Romorini, LeonardoIcon ; Fletcher, Sabrina JohannaIcon ; Vila, Antonella SofíaIcon ; Pereyra Bonnet, Federico AlbertoIcon ; Calvo, Juan CarlosIcon ; Chasseing, Norma AlejandraIcon ; Vellón, LucianoIcon
Tipo del evento: Reunión
Nombre del evento: Annual Meeting International Society for Stem Cell Research 2018: Envisión & engage
Fecha del evento: 20/06/2018
Institución Organizadora: International Society for Stem Cell Research; Australasian Society for Stem Cell Research;
Título del Libro: ISSCR 2018: Poster abstract book
Editorial: International Society for Stem Cell Research
Idioma: Inglés
Clasificación temática:

Resumen

The rate-limiting enzyme in the mevalonic acid (MVA) pathway, hydroxymethylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors, increasing the synthesis de novo of cholesterol, critical for cell survival and proliferation. However, the role of HMGCR in the induction and maintenance of stemness in both transformed and non-transformed cells is still unclear.
Palabras clave: HMGCR , CRISPR-CAS9 , BREAST CANCER , CANCER STEM CELLS
 
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Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/253222
URL: https://www.isscr.org/the-archives
Colecciones
Eventos(IBYME)
Eventos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Development of an hydroxymethylglutharyl-coenzyme a reductase (hmgcr) overexpression system for the study of reprogramming to stem-like states in human breast cancer; Annual Meeting International Society for Stem Cell Research 2018: Envisión & engage; Melbourne; Australia; 2018; 338-338
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