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dc.contributor.author
Ghosh, Rakesh
dc.contributor.author
Owa, Olorunfemi
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Santos, Nicole
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Butrick, Elizabeth
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Piaggio, Gilda
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Widmer, Mariana
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Althabe, Fernando

dc.contributor.author
Qureshi, Zahaida
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Lumbiganon, Pisake
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Katageri, Geetanjali
dc.contributor.author
Walker, Dilys
dc.date.available
2025-01-16T09:20:10Z
dc.date.issued
2023-06
dc.identifier.citation
Ghosh, Rakesh; Owa, Olorunfemi; Santos, Nicole; Butrick, Elizabeth; Piaggio, Gilda; et al.; Heat stable carbetocin or oxytocin for prevention of postpartum hemorrhage among women at risk: A secondary analysis of the CHAMPION trial; Wiley; International Journal of Gynecology Obstetrics; 164; 1; 6-2023; 124-130
dc.identifier.issn
0020-7292
dc.identifier.uri
http://hdl.handle.net/11336/252646
dc.description.abstract
ObjectiveTo examine whether the observed non-inferiority of heat-stable carbetocin (HSC), compared with oxytocin, was influenced by biologic (macrosomia, parity 3 or more, or history of postpartum hemorrhage [PPH]) and/or pharmacologic (induction or augmentation) risk factors for PPH.MethodsThe present study is a secondary analysis of the CHAMPION non-inferiority randomized trial—a two-arm, double-blind, active-controlled study conducted at 23 hospitals in 10 countries, between July 2015 and January 2018. Women with singleton pregnancies, expected to deliver vaginally with cervical dilatation up to 6 cm were eligible. Randomization was stratified by country, with 1:1 assignment. Women in the intervention and control groups received a single intramuscular injection of 100 μg of HSC or 10 IU of oxytocin, respectively. The drugs were administered immediately after birth, and the third stage of labor was managed according to the WHO guidelines. Blood was collected using a plastic drape. For this analysis, we defined a woman as being at risk if she had any one or more of the biologic or pharmacologic risk factor(s).ResultsThe HSC and oxytocin arms contained 14 770 and 14 768 women, respectively. The risk ratios (RR) for PPH were 1.29 (95% confidence interval [CI] 1.08–1.53) or 1.73 (95% CI 1.51–1.98) for those with only biologic (macrosomia, parity 3 or more, and PPH in the previous pregnancy) or only pharmacologic (induced or augmented) risk factors, respectively, compared with those with neither risk factors.ConclusionsFindings reinforce previous evidence that macrosomia, high parity, history of PPH, and induction/augmentation are risk factors for PPH. We did not find a difference in effects between HSC and oxytocin for PPH among women who were neither induced nor augmented or among those who were induced or augmented.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley

dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
PPH
dc.subject
PREVENTION
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CHAMPION trial
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Otras Ciencias de la Salud

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Ciencias de la Salud

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CIENCIAS MÉDICAS Y DE LA SALUD

dc.title
Heat stable carbetocin or oxytocin for prevention of postpartum hemorrhage among women at risk: A secondary analysis of the CHAMPION trial
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-11-27T15:11:40Z
dc.journal.volume
164
dc.journal.number
1
dc.journal.pagination
124-130
dc.journal.pais
Irlanda

dc.description.fil
Fil: Ghosh, Rakesh. University of California; Estados Unidos
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Fil: Owa, Olorunfemi. Mother And Child Hospital; Nigeria
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Fil: Santos, Nicole. University of California; Estados Unidos
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Fil: Butrick, Elizabeth. University of California; Estados Unidos
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Fil: Piaggio, Gilda. No especifíca;
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Fil: Widmer, Mariana. No especifíca;
dc.description.fil
Fil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
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Fil: Qureshi, Zahaida. University Of Nairobi; Kenia
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Fil: Lumbiganon, Pisake. Khon Kaen University; Tailandia
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Fil: Katageri, Geetanjali. S Nijalingappa Medical College; India
dc.description.fil
Fil: Walker, Dilys. University of California; Estados Unidos
dc.journal.title
International Journal of Gynecology Obstetrics

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14938
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ijgo.14938
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