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dc.contributor.author
Perez, Sandra  
dc.contributor.author
Gooz, Monika  
dc.contributor.author
Maldonado, Eduardo Néstor  
dc.date.available
2025-01-10T19:31:02Z  
dc.date.issued
2024-10  
dc.identifier.citation
Perez, Sandra; Gooz, Monika; Maldonado, Eduardo Néstor; Mitochondrial dysfunction and metabolic disturbances induced by viral infections; MDPI; Cells; 13; 21; 10-2024; 1-25  
dc.identifier.issn
2073-4409  
dc.identifier.uri
http://hdl.handle.net/11336/252290  
dc.description.abstract
Viruses are intracellular parasites that utilize organelles, signaling pathways, and the bioenergetics machinery of the cell to replicate the genome and synthesize proteins to build up new viral particles. Mitochondria are key to supporting the virus life cycle by sustaining energy production, metabolism, and synthesis of macromolecules. Mitochondria also contribute to the antiviral innate immune response. Here, we describe the different mechanisms involved in virus–mitochondria interactions. We analyze the effects of viral infections on the metabolism of glucose in the Warburg phenotype, glutamine, and fatty acids. We also describe how viruses directly regulate mitochondrial function through modulation of the activity of the electron transport chain, the generation of reactive oxygen species, the balance between fission and fusion, and the regulation of voltage-dependent anion channels. In addition, we discuss the evasion strategies used to avoid mitochondrial-associated mechanisms that inhibit viral replication. Overall, this review aims to provide a comprehensive view of how viruses modulate mitochondrial function to maintain their replicative capabilities.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
MDPI  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
MITOCHONDRIA  
dc.subject
GLUCOSE  
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VIRUS  
dc.subject
METABOLIC REPROGRAMMING  
dc.subject.classification
Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Mitochondrial dysfunction and metabolic disturbances induced by viral infections  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2025-01-10T13:38:53Z  
dc.journal.volume
13  
dc.journal.number
21  
dc.journal.pagination
1-25  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basilea  
dc.description.fil
Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina  
dc.description.fil
Fil: Gooz, Monika. Medical University Of South Carolina; Estados Unidos  
dc.description.fil
Fil: Maldonado, Eduardo Néstor. Medical University Of South Carolina; Estados Unidos  
dc.journal.title
Cells  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/13/21/1789  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cells13211789