Bioinformatic Analysis of Staphylococcus Phages: A Key Step for Safe Cocktail Development

Abstract

An in-depth analysis of phage genomic sequences is essential for the proposal of a cocktail for therapeutic uses. With the burst of publications on phage isolation and genetic studies during the last decade, several different bioinformatics programs have been used. Here we describe our studies on the genetic organization of phages infecting Staphylococcus aureus, a pathogen of human importance, by using an assembly of tools for gene annotation, identification of expression components, and phylogeny analysis.