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dc.contributor.author
Vigliecca, Nora Silvana
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dc.contributor.author
Molina, Silvia Cristina
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dc.contributor.author
Peñalva, Marisa Carola
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dc.date.available
2017-09-27T13:55:52Z
dc.date.issued
2006-02
dc.identifier.citation
Vigliecca, Nora Silvana; Molina, Silvia Cristina; Peñalva, Marisa Carola; A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile; Elsevier Inc; Journal Of Pharmacological And Toxicological Methods.; 55; 1; 2-2006; 49-57
dc.identifier.issn
1056-8719
dc.identifier.uri
http://hdl.handle.net/11336/25179
dc.description.abstract
Introduction: Clinical studies have shown that some antidepressants may be more efficient than benzodiazepines to alleviate anxiety associated with panic disorders; however, operant conflict procedures in rats developed so far seem not particularly able to model human anxiety sensitive to antidepressant treatments. Previous panic models with learned responses did not statistically subtract the effect of confounding factors from the variable of interest. Methods: Undernourished rats were selected due to their behavioral and neurobiological resemblance to human patients suffering from panic disorder. The Geller–Seifter paradigm represented the stressful environmental condition in adult life. Desipramine (10 mg/kg/day) or saline were administered IP during 7 days under a cross over design (N= 10). Five daily 15 min-operant sessions were carried out on each experiment. Unpunished, unrewarded and punished operant behavioral periods were identical both in their duration and in their reward system (the FR1 schedule) in order to measure response suppression, which has not been considered in previous studies with the Geller–Seifter paradigm. The dependent variable was the difference between comparable unpunished and punished periods. Results: A significant Diet × Drug interaction was observed in the dependent variable, which represented the level of “suppression/suppression release” induced by treatments. Discussion: Compared to control rats, deprived rats showed a significant and selective anticonflict effect of desipramine on the stressful and complex operant performance. The animal model of perinatally protein-deprived rats along with the Geller–Seifter's operant behavioral paradigm may represent a more sensitive approach to model human anxiety sensitive to antidepressant treatments by considering the combined impact of both early biological trauma and adult learned experiences under the same design.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Methodology
dc.subject
Pharmacology
dc.subject
Behavioral
dc.subject
Cognition
dc.subject.classification
Otras Psicología
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dc.subject.classification
Psicología
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dc.subject.classification
CIENCIAS SOCIALES
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dc.title
A panic experimental model: Validation of a complex operant behavioral method in undernourished rats, with desipramine to provide a template effect profile
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-12T20:29:59Z
dc.journal.volume
55
dc.journal.number
1
dc.journal.pagination
49-57
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Vigliecca, Nora Silvana. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Molina, Silvia Cristina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina
dc.description.fil
Fil: Peñalva, Marisa Carola. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Centro de Investigaciones Maria Saleme Burnichón; Argentina
dc.journal.title
Journal Of Pharmacological And Toxicological Methods.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vascn.2006.02.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1056871906000256
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