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dc.contributor.author
Borosky, Gabriela Leonor
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dc.date.available
2017-09-27T13:54:30Z
dc.date.issued
2013-01
dc.identifier.citation
Borosky, Gabriela Leonor; Quantum-chemical studies on mutagenicity of aromatic and heteroaromatic amines
; Frontiers in Bioscience; Frontiers In Bioscience-landmark; 1-2013; 600-610
dc.identifier.issn
1093-9946
dc.identifier.uri
http://hdl.handle.net/11336/25172
dc.description.abstract
With the prospect of potential treatments for Huntington's disease (HD), non-invasive markers of disease progression are needed. Cognitive impairment has long been recognised as one of the core symptoms of HD. The first aim of this review is to provide insight into the onset and nature of cognitive loss in the progressing stages of HD. The second aim is to provide an overview of the cognitive functions that have been examined in an attempt to identify those areas that have the most potential to yield a cognitive biomarker. Literature, consisting of 110 studies, since the implementation of genetic testing until the beginning of 2011 has been included in this review. The clinical features of premanifest HD include deficits in psychomotor speed, negative emotion recognition and to some extent in executive functioning. The clinical profile of manifest HD includes impairment in memory, psychomotor speed, negative emotion recognition and executive functioning. Furthermore, potential candidate biomarkers should be most expected from such domains as working memory, psychomotor speed, recognition of negative emotions, attentional and visuospatial executive functions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in Bioscience
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aromatic And Heteroaromatic Amines
dc.subject
Mutagenic Activity
dc.subject
Quantum-Mechanical Calculations
dc.subject
Nitrenium Ions
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Quantum-chemical studies on mutagenicity of aromatic and heteroaromatic amines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-09T14:25:21Z
dc.journal.pagination
600-610
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Borosky, Gabriela Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.journal.title
Frontiers In Bioscience-landmark
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bioscience.org/2013/v5s/af/393/list.htm
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