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dc.contributor.author
Martín, Mauricio Gerardo  
dc.contributor.author
Dotti, Carlos  
dc.date.available
2025-01-03T13:34:44Z  
dc.date.issued
2023-08  
dc.identifier.citation
Martín, Mauricio Gerardo; Dotti, Carlos; Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 194; 106879; 8-2023; 1-2  
dc.identifier.issn
1043-6618  
dc.identifier.uri
http://hdl.handle.net/11336/251688  
dc.description.abstract
Huntington's Disease (HD) is a devastating neurodegenerative disorder characterized by progressive cognitive and motor impairment. Multiple studies have shown impaired cholesterol biosynthesis in the brains of HD patients and various rodent models and different strategies have explored to which extent modulation of brain cholesterol levels could be beneficial for HD cognitive and motor deficits. The work titled "Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease" by Birolini et al. is the culmination of 25 years of effort by Elena Cattaneo's research group in this area...  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press Ltd - Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
CHOLESTEROL  
dc.subject
HUNTINGTON  
dc.subject
THERAPY  
dc.subject
NEURODEGENERATION  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-11-12T13:59:25Z  
dc.journal.volume
194  
dc.journal.number
106879  
dc.journal.pagination
1-2  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: Dotti, Carlos. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España  
dc.journal.title
Pharmacological Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phrs.2023.106879  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043661823002359  

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