Evento
The metabotropic glutamate receptor homologs MGL-1 and MGL-2 are key for sensing nutritional status in C. elegans
Tipo del evento:
Conferencia
Nombre del evento:
24th international C. elegans conference
Fecha del evento:
24/06/2023
Institución Organizadora:
Genetics Society of America;
Título del Libro:
24th International C. elegans Conference
Título de la revista:
Worm 23 abstract book
Editorial:
Genetics Society of America
Idioma:
Inglés
Clasificación temática:
Resumen
The mechanisms that allow the nervous system (NS) to sense nutritional state and adapt animal behavior are poorly understood in most species. The simplicity of its NS and its known connectome make C. elegans a useful system to study these mechanisms. Results from our laboratory showed that inhibition of the tyraminergic neuron RIM during fasting, enhances serotonin release from other neurons when the animal reencounters food, allowing it to slow down locomotion and start feeding. Mutations in the GPCRs, MGL-1 and MGL-2, located in two presynaptic interneurons to RIM have been reported to induce autophagy even in well-fed animals. Here, we performed behavioral assays on mgl-1; mgl-2 double mutants. We found that these animals, even when well fed, show a significant decrease in locomotion when they find food, similar to fasted wild-type animals. Moreover, when we exposed these mutants to GFP-expressing bacteria, the fluorescence in the intestine is higher than that of wild-type animals, suggesting a higher feeding rate. These initial results suggest that the metabotropic receptors MGL-1 and MGL-2 are key for satiation sensing. We propose, therefore, to determine what these satiety signals are and the neuronal circuits involved. Given that this behavioral plasticity modulated by the nutritional state is observed throughout the animal kingdom, and that several fundamental processes are highly conserved, these results may provide universally relevant information.
Palabras clave:
C.ELEGANS
,
NEURAL CIRCUIT
,
NUTRITION
,
METABOTROPIC RECEPTORS
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Eventos(INIBIBB)
Eventos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Eventos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
The metabotropic glutamate receptor homologs MGL-1 and MGL-2 are key for sensing nutritional status in C. elegans; 24th international C. elegans conference; Glasgow; Reino Unido; 2023; 389-389
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