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dc.contributor.author
Mateo Fernández, Marcos
dc.contributor.author
Merinas Amo, Tania
dc.contributor.author
Moreno Millán, Miguel
dc.contributor.author
Alonso Moraga, Ángeles
dc.contributor.author
Demyda-peyrás, Sebastian
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dc.date.available
2017-09-25T15:12:31Z
dc.date.issued
2016-05
dc.identifier.citation
Mateo Fernández, Marcos; Merinas Amo, Tania; Moreno Millán, Miguel; Alonso Moraga, Ángeles; Demyda-peyrás, Sebastian; In Vivo and In Vitro Genotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approach; Hindawi Publishing Corporation; BioMed Research International; 2016; 5-2016; 1-15
dc.identifier.issn
2314-6133
dc.identifier.uri
http://hdl.handle.net/11336/25034
dc.description.abstract
The aim of this work was to assess the biological and food safety of two different beverages: Classic Coca Cola (CCC) and CaffeineFree Coca Cola (CFCC). To this end, we determined the genotoxicological and biological effects of different doses of lyophilised CCC and CFCC and Caffeine (CAF), the main distinctive constituent. Their toxic/antitoxic, genotoxic/antigenotoxic, and chronic toxicity (lifespan assay) effects were determined in vivo using the Drosophila model. Their cytotoxic activities were determined using the HL-60 in vitro cancer model. In addition, clastogenic DNA toxicity was measured using internucleosomal fragmentation and SCGE assays. Their epigenetic effects were assessed on the HL-60 methylation status using some repetitive elements. The experimental results showed a slight chemopreventive effect of the two cola beverages against HL-60 leukaemia cells, probably mediated by nonapoptotic mechanisms. Finally, CCC and CAF induced a global genome hypomethylation evaluated in LINE-1 and Alu M1 repetitive elements. Overall, we demonstrated for the first time the safety of this famous beverage in in vivo and in vitro models.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Coca Cola
dc.subject
Gentoxicity
dc.subject.classification
Ética relacionada con Biotecnología Médica
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
In Vivo and In Vitro Genotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approach
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-19T14:19:33Z
dc.identifier.eissn
2314-6141
dc.journal.volume
2016
dc.journal.pagination
1-15
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Mateo Fernández, Marcos. Universidad de Córdoba. Departamento de Genética. Córdoba; España
dc.description.fil
Fil: Merinas Amo, Tania. Universidad de Córdoba. Departamento de Genética. Córdoba; España
dc.description.fil
Fil: Moreno Millán, Miguel. Universidad de Córdoba. Departamento de Genética. Córdoba; España
dc.description.fil
Fil: Alonso Moraga, Ángeles. Universidad de Córdoba. Departamento de Genética. Córdoba; España
dc.description.fil
Fil: Demyda-peyrás, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.journal.title
BioMed Research International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2016/7574843
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2016/7574843/
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