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Artículo

Gender differences in cardiac left ventricular mass and function: clinical and experimental observations

Escudero, Eduardo Manuel; Orlowski, AlejandroIcon ; Diaz, Alejandro; Pinilla, Oscar AndresIcon ; Ennis, Irene LuciaIcon ; Aiello, Ernesto AlejandroIcon
Fecha de publicación: 01/2014
Editorial: Via Medica
Revista: Cardiology Journal
ISSN: 1897-5593
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and humans by echocardiography and LVM index (LVMI) was obtained. Results: LVMI, myocyte area and CVF were similar in males and females of 1-month-old rats. LVMI in children was similar in both genders. In contrast, in 6-month-old rats (5 males and 5 females), LVMI (17.7 ± 0.7 mg/mm vs. 10.1 ± 0.2 mg/mm; p < 0.01), and myocyte area (4572.5 ± 72.6 μm2 vs. 3293.85 ± 57.8 μm2 , p < 0.01) were higher in male animals without differences in CVF. Men (n = 25) exhibited greater LVMI than women (n = 25) (77.4 ± 3.2 g/m2 vs. 63.3 ± 1.8 g/m2 , p < 0.01), whereas the LVF was higher in women (105.9 ± 2.9% vs. 95.3 ± 3.5%, p < 0.01). Conclusions: There is a clear gender-associated impact on LVM with aging in humans and rats. Similar CVF and LVF associated to greater myocyte size and LVM in male rats suggest a process of physiological response. However, the increase in cardiac mass without an associated improved cardiac function in men in comparison to women could likely represent a potential disadvantage in the adaptive response during growth. (Cardiol J 2014; 21, 1: x–x)
Palabras clave: Cardiac Myocytes , Sex Differences , Cardiac Function , Cardiac Hypertrophy
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/25024
DOI: http://dx.doi.org/10.5603/CJ.a2013.0105
URL: https://journals.viamedica.pl/cardiology_journal/article/view/29758
Colecciones
Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
Escudero, Eduardo Manuel; Orlowski, Alejandro; Diaz, Alejandro; Pinilla, Oscar Andres; Ennis, Irene Lucia; et al.; Gender differences in cardiac left ventricular mass and function: clinical and experimental observations; Via Medica; Cardiology Journal; 21; 1; 1-2014; 53-59
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