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dc.contributor.author
Luzarowska, Urszula  
dc.contributor.author
Ruß, Anne-Kathrin  
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Joubès, Jérôme  
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Batsale, Marguerite  
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Szymanski, Jedrzej  
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Thirumalaikumar, Venkatesh Periyakavanam  
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Luzarowski, Marcin  
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Wu, Si  
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Zhu, Feng  
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Endres, Niklas  
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Khedhayir, Sarah  
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Schumacher, Julia  
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Jasinska, Weronika  
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Xu, Ke  
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Correa Córdoba, Sandra Marcela  
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Weil, Simy  
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Skirycz, Aleksandra  
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Fernie, Alisdair Robert  
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Li-Beisson, Yonghua  
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Fusari, Corina Mariana  
dc.contributor.author
Brotman, Yariv  
dc.date.available
2024-12-10T09:44:34Z  
dc.date.issued
2023-06  
dc.identifier.citation
Luzarowska, Urszula; Ruß, Anne-Kathrin; Joubès, Jérôme; Batsale, Marguerite; Szymanski, Jedrzej; et al.; Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana; American Society of Plant Biologist; Plant Cell; 35; 6; 6-2023; 1984-2005  
dc.identifier.issn
1040-4651  
dc.identifier.uri
http://hdl.handle.net/11336/249975  
dc.description.abstract
Plant lipids are important as alternative sources of carbon and energy when sugars or starch are limited. Here, we applied combined heat and darkness or extended darkness to a panel of ∼ 300 Arabidopsis (Arabidopsis thaliana) accessions to study lipid remodeling under carbon starvation. Natural allelic variation at 3-KETOACYL-COENZYME A SYNTHASE4 (KCS4), a gene encoding an enzyme involved in very long chain fatty-acid (VLCFA) synthesis, underlies the differential accumulation of polyunsaturated triacylglycerols (puTAGs) under stress. Ectopic expression of KCS4 in yeast and plants proved that KCS4 is a functional enzyme localized in the endoplasmic reticulum with specificity for C22 and C24 saturated acyl-CoA. Allelic mutants and transient overexpression in planta revealed the differential role of KCS4 alleles in VLCFA synthesis and leaf wax coverage, puTAG accumulation and biomass. Moreover, the region harboring KCS4 is under high selective pressure and allelic variation at KCS4 correlated with environmental parameters from the locales of Arabidopsis accessions. Our results provide evidence that KCS4 plays a decisive role in the subsequent fate of fatty acids released from chloroplast membrane lipids under carbon starvation. This work sheds light on both plant response mechanisms and the evolutionary events shaping the lipidome under carbon starvation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Society of Plant Biologist  
dc.rights
info:eu-repo/semantics/openAccess  
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https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ARABIDOPSIS  
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GWAS  
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NATURAL VARIATION  
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TRIACYLGLYCEROLS  
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FATTY ACIDS  
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KCS4  
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CARBON STARVATION  
dc.subject.classification
Genética y Herencia  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-04-22T11:53:04Z  
dc.journal.volume
35  
dc.journal.number
6  
dc.journal.pagination
1984-2005  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Rockville  
dc.description.fil
Fil: Luzarowska, Urszula. Ben Gurion University of the Negev; Israel  
dc.description.fil
Fil: Ruß, Anne-Kathrin. Max Planck Institute Of Molecular Plant Physiology; Alemania  
dc.description.fil
Fil: Joubès, Jérôme. Université de Bordeaux; Francia  
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Fil: Batsale, Marguerite. Université de Bordeaux; Francia  
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Fil: Szymanski, Jedrzej. Leibniz Institute of Plant Genetics and Crop Plant Research; Alemania. Ibg-4 Bioinformatics; Alemania  
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Fil: Thirumalaikumar, Venkatesh Periyakavanam. Max Planck Institute Of Molecular Plant Physiology; Alemania  
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Fil: Luzarowski, Marcin. Max Planck Institute Of Molecular Plant Physiology; Alemania  
dc.description.fil
Fil: Wu, Si. University of Stanford; Estados Unidos  
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Fil: Zhu, Feng. Max Planck Institute Of Molecular Plant Physiology; Alemania. Huazhong Agricultural University; China  
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Fil: Endres, Niklas. Max Planck Institute Of Molecular Plant Physiology; Alemania  
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Fil: Khedhayir, Sarah. Max Planck Institute Of Molecular Plant Physiology; Alemania  
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Fil: Schumacher, Julia. Humboldt-Universität zu Berlin; Alemania  
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Fil: Jasinska, Weronika. Ben Gurion University of the Negev; Israel  
dc.description.fil
Fil: Xu, Ke. Max Planck Institute Of Molecular Plant Physiology; Alemania  
dc.description.fil
Fil: Correa Córdoba, Sandra Marcela. Ben Gurion University of the Negev; Israel  
dc.description.fil
Fil: Weil, Simy. Ben Gurion University of the Negev; Israel  
dc.description.fil
Fil: Skirycz, Aleksandra. Max Planck Institute Of Molecular Plant Physiology; Alemania  
dc.description.fil
Fil: Fernie, Alisdair Robert. Max Planck Institute Of Molecular Plant Physiology; Alemania  
dc.description.fil
Fil: Li-Beisson, Yonghua. Aix Marseille Université; Francia  
dc.description.fil
Fil: Fusari, Corina Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Centro de Estudios Fotosintéticos y Bioquímicos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina  
dc.description.fil
Fil: Brotman, Yariv. Ben Gurion University of the Negev; Israel  
dc.journal.title
Plant Cell  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/plcell/advance-article/doi/10.1093/plcell/koad059/7068315  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/plcell/koad059