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dc.contributor.author
Jolly, Ana  
dc.contributor.author
Fernández, Bárbara  
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Mundo, Silvia Leonor  
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Elguezabal, Natalia  
dc.date.available
2024-12-10T00:06:01Z  
dc.date.issued
2023-11  
dc.identifier.citation
Jolly, Ana; Fernández, Bárbara; Mundo, Silvia Leonor; Elguezabal, Natalia; Modeling Paratuberculosis in Laboratory Animals, Cells, or Tissues: A Focus on Their Applications for Pathogenesis, Diagnosis, Vaccines, and Therapy Studies; Multidisciplinary Digital Publishing Institute; Animals; 13; 22; 11-2023; 1-27  
dc.identifier.issn
2076-2615  
dc.identifier.uri
http://hdl.handle.net/11336/249956  
dc.description.abstract
Paratuberculosis is a chronic granulomatous enteritis caused by Mycobacterium avium subsp. Paratuberculosis that affects a wide variety of domestic and wild animals. It is considered one of the diseases with the highest economic impact on the ruminant industry. Despite many efforts and intensive research, paratuberculosis control still remains controversial, and the existing diagnostic and immunoprophylactic tools have great limitations. Thus, models play a crucial role in understanding the pathogenesis of infection and disease, and in testing novel vaccine candidates. Ruminant animal models can be restricted by several reasons, related to space requirements, the cost of the animals, and the maintenance of the facilities. Therefore, we review the potential and limitations of the different experimental approaches currently used in paratuberculosis research, focusing on laboratory animals and cell-based models. The aim of this review is to offer a vision of the models that have been used, and what has been achieved or discovered with each one, so that the reader can choose the best model to answer their scientific questions and prove their hypotheses. Also, we bring forward new approaches that we consider worth exploring in the near future.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Multidisciplinary Digital Publishing Institute  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
EPITHELIAL CELL  
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EX VIVO  
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EXPERIMENTAL INFECTION  
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IN VITRO  
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IN VIVO  
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INFECTION MODEL  
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MACROPHAGE  
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NEUTROPHIL  
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PARATUBERCULOSIS  
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RABBIT  
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Otras Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Modeling Paratuberculosis in Laboratory Animals, Cells, or Tissues: A Focus on Their Applications for Pathogenesis, Diagnosis, Vaccines, and Therapy Studies  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-11-22T12:50:25Z  
dc.journal.volume
13  
dc.journal.number
22  
dc.journal.pagination
1-27  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Jolly, Ana. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Fernández, Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina  
dc.description.fil
Fil: Mundo, Silvia Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina  
dc.description.fil
Fil: Elguezabal, Natalia. No especifíca;  
dc.journal.title
Animals  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2615/13/22/3553  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ani13223553