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dc.contributor.author Leuner, Kristina
dc.contributor.author Li, Wei
dc.contributor.author Amaral, Michelle D.
dc.contributor.author Rudolph, Stephanie
dc.contributor.author Calfa, Gaston Diego
dc.contributor.author Schuwald, Anita M.
dc.contributor.author Harteneck, Christian
dc.contributor.author Inoue, Takafumi
dc.contributor.author Pozzo Miller, Lucas
dc.date.available 2017-09-22T17:46:47Z
dc.date.issued 2012-07
dc.identifier.citation Leuner, Kristina; Li, Wei; Amaral, Michelle D.; Rudolph, Stephanie; Calfa, Gaston Diego; et al.; Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+- permeable TRPC6 channels; Wiley; Hippocampus; 23; 1; 7-2012; 40-52
dc.identifier.issn 1050-9631
dc.identifier.uri http://hdl.handle.net/11336/24943
dc.description.abstract The standardized extract of the St. John's wort plant (Hypericum perforatum) is commonly used to treat mild to moderate depression. Its active constituent is hyperforin, a phloroglucinol derivative that reduces the reuptake of serotonin and norepinephrine by increasing intracellular Na+ concentration through the activation of nonselective cationic TRPC6 channels. TRPC6 channels are also Ca2+-permeable, resulting in intracellular Ca2+ elevations. Indeed, hyperforin activates TRPC6-mediated currents and Ca2+ transients in rat PC12 cells, which induce their differentiation, mimicking the neurotrophic effect of nerve growth factor. Here, we show that hyperforin modulates dendritic spine morphology in CA1 and CA3 pyramidal neurons of hippocampal slice cultures through the activation of TRPC6 channels. Hyperforin also evoked intracellular Ca2+ transients and depolarizing inward currents sensitive to the TRPC channel blocker La3+, thus resembling the actions of the neurotrophin brain-derived neurotrophic factor (BDNF) in hippocampal pyramidal neurons. These results suggest that the antidepressant actions of St. John's wort are mediated by a mechanism similar to that engaged by BDNF.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject HIPPOCAMPUS
dc.subject TRPC6
dc.subject SIRNA
dc.subject ORGANOTIPIC SLICES
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+- permeable TRPC6 channels
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-08-09T14:25:24Z
dc.journal.volume 23
dc.journal.number 1
dc.journal.pagination 40-52
dc.journal.pais Estados Unidos
dc.journal.ciudad Hoboken
dc.description.fil Fil: Leuner, Kristina. University of Alabama at Birmingahm; Estados Unidos. Goethe Universitat Frankfurt; Alemania
dc.description.fil Fil: Li, Wei. University of Alabama at Birmingahm; Estados Unidos
dc.description.fil Fil: Amaral, Michelle D.. University of Alabama at Birmingahm; Estados Unidos
dc.description.fil Fil: Rudolph, Stephanie. University of Alabama at Birmingahm; Estados Unidos. University of Freiburg; Alemania
dc.description.fil Fil: Calfa, Gaston Diego. University of Alabama at Birmingahm; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil Fil: Schuwald, Anita M.. Goethe Universitat Frankfurt; Alemania
dc.description.fil Fil: Harteneck, Christian. Eberhard-Karls University; Alemania
dc.description.fil Fil: Inoue, Takafumi. Waseda University; Japón
dc.description.fil Fil: Pozzo Miller, Lucas. University of Alabama at Birmingahm; Estados Unidos
dc.journal.title Hippocampus
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hipo.22052
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hipo.22052/abstract


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    Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)