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dc.contributor.author
Leuner, Kristina
dc.contributor.author
Li, Wei
dc.contributor.author
Amaral, Michelle D.
dc.contributor.author
Rudolph, Stephanie
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Calfa, Gaston Diego
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Schuwald, Anita M.
dc.contributor.author
Harteneck, Christian
dc.contributor.author
Inoue, Takafumi
dc.contributor.author
Pozzo Miller, Lucas
dc.date.available
2017-09-22T17:46:47Z
dc.date.issued
2012-07
dc.identifier.citation
Leuner, Kristina; Li, Wei; Amaral, Michelle D.; Rudolph, Stephanie; Calfa, Gaston Diego; et al.; Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+- permeable TRPC6 channels; Wiley; Hippocampus; 23; 1; 7-2012; 40-52
dc.identifier.issn
1050-9631
dc.identifier.uri
http://hdl.handle.net/11336/24943
dc.description.abstract
The standardized extract of the St. John's wort plant (Hypericum perforatum) is commonly used to treat mild to moderate depression. Its active constituent is hyperforin, a phloroglucinol derivative that reduces the reuptake of serotonin and norepinephrine by increasing intracellular Na+ concentration through the activation of nonselective cationic TRPC6 channels. TRPC6 channels are also Ca2+-permeable, resulting in intracellular Ca2+ elevations. Indeed, hyperforin activates TRPC6-mediated currents and Ca2+ transients in rat PC12 cells, which induce their differentiation, mimicking the neurotrophic effect of nerve growth factor. Here, we show that hyperforin modulates dendritic spine morphology in CA1 and CA3 pyramidal neurons of hippocampal slice cultures through the activation of TRPC6 channels. Hyperforin also evoked intracellular Ca2+ transients and depolarizing inward currents sensitive to the TRPC channel blocker La3+, thus resembling the actions of the neurotrophin brain-derived neurotrophic factor (BDNF) in hippocampal pyramidal neurons. These results suggest that the antidepressant actions of St. John's wort are mediated by a mechanism similar to that engaged by BDNF.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hippocampus
dc.subject
Trpc6
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Sirna
dc.subject
Organotipic Slices
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+- permeable TRPC6 channels
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-09T14:25:24Z
dc.journal.volume
23
dc.journal.number
1
dc.journal.pagination
40-52
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Leuner, Kristina. University of Alabama at Birmingahm; Estados Unidos. Goethe Universitat Frankfurt; Alemania
dc.description.fil
Fil: Li, Wei. University of Alabama at Birmingahm; Estados Unidos
dc.description.fil
Fil: Amaral, Michelle D.. University of Alabama at Birmingahm; Estados Unidos
dc.description.fil
Fil: Rudolph, Stephanie. University of Alabama at Birmingahm; Estados Unidos. University of Freiburg; Alemania
dc.description.fil
Fil: Calfa, Gaston Diego. University of Alabama at Birmingahm; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Schuwald, Anita M.. Goethe Universitat Frankfurt; Alemania
dc.description.fil
Fil: Harteneck, Christian. Eberhard-Karls University; Alemania
dc.description.fil
Fil: Inoue, Takafumi. Waseda University; Japón
dc.description.fil
Fil: Pozzo Miller, Lucas. University of Alabama at Birmingahm; Estados Unidos
dc.journal.title
Hippocampus
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hipo.22052
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hipo.22052/abstract
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